Abstract: Objective  To observe the curative effect and life quality improvement in patients with intractable neuropathic pain (NP) after implanting a programmable continuous intrathecal infusion pump.  Methods  Three cases of intractable neuropathic pain with poor medicine efficacy or serious adverse drug reactions had been followed-up for 6-14 months after being implanted programmable intrathecal infusion pump. Pain relief, sleep quality improvement, dosage of oral analgesics and drug side effect were observed.  Results  After treatment the Visual Analogue Scale (VAS) of 3 patients decreased significantly, with pain releasing from preoperative moderate or severe pain to postoperative mild pain and decrease of fulminating pain frequency. Dosage of oral analgesics declined to 10% of its preoperative dose and sleep quality was improved obviously. Neither postoperative complications nor side effect of morphine was observed during the follow-up.  Conclusion  The treatment of implanting a totally programmable continuous intrathecal infusion pump is eutherapeutic to the patients with intractable neuropathic pain who have achieved satisfactory analgesic effect in experimental therapy.

Key words: Pain, intractable, Infusion pumps, implantable, Morphine

摘要： 目的 观察鞘内药物输注系统植入术治疗难治性神经病理性疼痛的疗效，以及对患者生活质量的改善情况。方法 采用鞘内药物输注系统植入术治疗3 例典型神经病理性疼痛且药物治疗效果欠佳，或出现严重药物不良反应患者，共随访6 ~ 14 个月，观察疼痛缓解率、睡眠改善程度、镇痛药物服用剂量及药物不良反应。结果 治疗后3 例患者视觉模拟评分均显著下降，由术前的中至重度疼痛改善至术后轻度疼痛，爆发痛次数减少；镇痛药物服用剂量约降至术前的10%；睡眠质量明显改善。随访期间均未发生手术相关性并发症和吗啡不良反应。结论 鞘内药物输注系统对经鞘内吗啡试验镇痛效果满意的难治性神经病理性疼痛患者具有较为肯定的近期疗效。

关键词: 疼痛, 顽固性, 输注泵, 植入型, 吗啡