脑深部电刺激术治疗Meige综合征抑郁和睡眠障碍非运动症状初探

doi:10.3969/j.issn.1672-6731.2020.12.008

摘要/Abstract

摘要：

目的总结Meige综合征抑郁和睡眠障碍等非运动症状特点，初步探讨脑深部电刺激术对非运动症状的有效性。方法采用脑深部电刺激术治疗2019年2-5月确诊的Meige综合征患者共计12例，分别于术前和术后3、6、12个月随访时评价抑郁[抑郁自评量表（SDS）]和睡眠障碍[匹兹堡睡眠质量指数（PQSI）]严重程度。结果术前共计9/12例患者存在不同程度抑郁和睡眠障碍，术后3、6和12个月随访时，抑郁和睡眠障碍比例分别为8/12和9/12例、8/12和9/12例、6/12和10/12例，手术前后抑郁（χ²=3.102，P=0.376）和睡眠障碍（χ²=2.598，P=0.458）发生率差异无统计学意义。结论 Meige综合征患者普遍存在抑郁和睡眠障碍，脑深部电刺激术对其非运动症状无明显改善作用。

关键词: Meige综合征, 抑郁, 入睡和睡眠障碍, 深部脑刺激法

Abstract:

Objective To summarize the characteristics of non-motor symptoms of Meige's syndrome(MS), including depression and sleep disorders, and to explore the effect of deep brain stimulation (DBS) on these non-motor symptoms. Methods Twelve patients with MS treated with DBS were recruited from February to May 2019 in Department of Neurosurgery in Peking University People's Hospital. The Self-Rating Depression Scale (SDS) and Pittsburgh Sleep Quality Index (PQSI) were used to assess the depression and sleep disorders before surgery and 3, 6 and 12 months after surgery. Results Before surgery, 9 (9/12) patients had different degrees of depression and sleep disorders. At 3 months after surgery, 8 (8/12) patients had different degrees of depression and 9 (9/12) had different degrees of sleep disorders. At 6 months after surgery, 8 (8/12) patients had different degrees of depression and 9 (9/12) had different degrees of sleep disorders. At 12 months after surgery, 6 (6/12) patients had different degrees of depression and 10 (10/12) had different degrees of sleep disorders. There was no significant difference in the proportion of depression (χ²=3.102, P=0.376) and sleep disorders (χ²=2.598, P=0.458) before and after DBS. Conclusions Depression and sleep disorders are common in patients with MS, and there is no significant improvement after DBS.

Key words: Meige syndrome, Depression, Sleep initiation and maintenance disorders, Deep brain stimulation

郝庆沛, 丁虎, 刘如恩. 脑深部电刺激术治疗Meige综合征抑郁和睡眠障碍非运动症状初探[J]. 中国现代神经疾病杂志, 2020, 20(12): 1072-1075.

HAO Qing-pei, DING Hu, LIU Ru-en. Deep brain stimulation for non-motor symptoms of depression and sleep disorders in Meige's syndrome[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2020, 20(12): 1072-1075.

https://journal11.magtechjournal.com/cjcnn/CN/Y2020/V20/I12/1072

参考文献

[1] Balint B, Bhatia KP. Dystonia:an update on phenomenology, classification, pathogenesis and treatment[J]. Curr Opin Neurol, 2014, 27:468-476.
[2] Albanese A, Bhatia K, Bressman SB, Delong MR, Fahn S, Fung VS, Hallett M, Jankovic J, Jinnah HA, Klein C, Lang AE, Mink JW, Teller JK. Phenomenology and classification of dystonia:a consensus update[J]. Mov Disord, 2013, 28:863-873.
[3] Tomic S, Petkovic I, Pucic T, Resan B, Juric S, Rotim T. Cervical dystonia and quality of life[J]. Acta Neurol Belg, 2016, 116:589-592.
[4] Uitti RJ. Treatment of Parkinson's disease:focus on quality of life issues[J]. Parkinsonism Relat Disord, 2012, 18 Suppl 1:34-36.
[5] Pekmezovic T, Svetel M, Ivanovic N, Dragasevic N, Petrovic I, Tepavcevic DK, Kostic VS. Quality of life in patients with focal dystonia[J]. Clin Neurol Neurosurg, 2009, 111:161-164.
[6] Thase ME. Correlates and consequences of chronic insomnia[J]. Gen Hosp Psychiatry, 2005, 27:100-112.
[7] Silvestri R, De Domenico P, Di Rosa AE, Bramanti P, Serra S, Di Perri R. The effect of nocturnal physiological sleep on various movementdisorders[J]. Mov Disord, 1990, 5:8-14.
[8] Shulman LM, Taback RL, Bean J, Weiner WJ. Comorbidity of the nonmotor symptoms of Parkinson's disease[J]. Mov Disord, 2001, 16:507-510.
[9] Moraru E, Schnider P, Wimmer A, Wenzel T, Birner P, Griengl H, Auff E. Relation between depression and anxiety in dystonic patients:implications for clinical management[J]. Depress Anxiety, 2002, 16:100-103.
[10] Gündel H, Busch R, Ceballos-Baumann A, Seifert E. Psychiatric comorbidity in patients with spasmodic dysphonia:a controlled study[J]. J Neurol Neurosurg Psychiatry, 2007, 78:1398-1400.
[11] Berardelli I, Ferrazzano G, Pasquini M, Biondi M, Berardelli A, Fabbrini G. Clinical course of psychiatric disorders in patients with cervical dystonia[J]. Psychiatry Res, 2015, 229(1/2):583-585.
[12] Eichenseer SR, Stebbins GT, Comella CL. Beyond a motor disorder:a prospective evaluation of sleep quality in cervical dystonia[J]. Parkinsonism Relat Disord, 2014, 20:405-408.
[13] Kuyper DJ, Parra V, Aerts S, Okun MS, Kluger BM. Nonmotor manifestations of dystonia:a systematic review[J]. Mov Disord, 2011, 26:1206-1217.
[14] Sprenger F, Poewe W. Management of motor and non-motor symptoms in Parkinson's disease[J]. CNS Drugs, 2013, 27:259-272.
[15] Czyz CN, Burns JA, Petrie TP, Watkins JR, Cahill KV, Foster JA. Long-term botulinum toxin treatment of benign essential blepharospasm, hemifacial spasm, and Meige syndrome[J]. Am J Ophthalmol, 2013, 156:173-177.
[16] Houser M, Waltz T. Meige syndrome and pallidal deep brain stimulation[J]. Mov Disord, 2005, 20:1203-1205.
[17] Zung WW. Factors influencing the self-rating depression scale[J]. Arch Gen Psychiatry, 1967, 16:543-547.
[18] Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The pittsburgh sleep quality index:a new instrument for psychiatric practice and research[J]. Psychiatry Res, 1989, 28:193-213.
[19] Buysse DJ, Reynolds CF 3rd, Monk TH, Hoch CC, Yeager AL, Kupfer DJ. Quantification of subjective sleep quality in healthy elderly men and women using the pittsburgh sleep quality index (PSQI)[J]. Sleep, 1991, 14:331-338.
[20] Åkerstedt T, Hume K, Minors D, Waterhouse J. The meaning of good sleep:a longitudinal study of polysomnography and subjective sleep quality[J]. J Sleep Res, 1994, 3:152-158.
[21] Vitiello MV, Larsen LH, Moe KE. Age-related sleep change:gender and estrogen effects on the subjective-objective sleep quality relationships of healthy, noncomplaining older men and women[J]. J Psychosom Res, 2004, 56:503-510.
[22] Huber SJ, Paulson GW, Shuttleworth EC. Relationship of motor symptoms, intellectual impairment, and depression in Parkinson's disease[J]. J Neurol Neurosurg Psychiatry, 1988, 51:855-858.
[23] Ben-Shlomo Y, Camfield L, Warner T; ESDE Collaborative Group. What are the determinants of quality of life in people with cervical dystonia[J]? J Neurol Neurosurg Psychiatry, 2002, 72:608-614.
[24] Mayer G, Jennum P, Riemann D, Dauvilliers Y. Insomnia in central neurologic diseases:occurrence and management[J]. Sleep Med Rev, 2011, 15:369-378.
[25] Bollu PC, Sahota P. Sleep and Parkinson disease[J]. Mo Med, 2017, 114:381-386.
[26] Zoons E, Tijssen MA, Dreissen YE, Speelman JD, Smit M, Booij J. The relationship between the dopaminergic system and depressive symptoms in cervical dystonia[J]. Eur J Nucl Med Mol Imaging, 2017, 44:1375-1382.
[27] Miller KM, Okun MS, Fernandez HF, Jacobson CE 4th, Rodriguez RL, Bowers D. Depression symptoms in movement disorders:comparing Parkinson's disease, dystonia, and essential tremor[J]. Mov Disord, 2007, 22:666-672.
[28] Ohayon MM. Epidemiology of insomnia:what we know and what we still need to learn[J]. Sleep Med Rev, 2002, 6:97-111.
[29] Hertenstein E, Tang NK, Bernstein CJ, Nissen C, Underwood MR, Sandhu HK. Sleep in patients with primary dystonia:a systematic review on the state of research and perspectives[J]. Sleep Med Rev, 2016, 26:95-107.
[30] Maquet P, Phillips C. Functional brain imaging of human sleep[J]. J Sleep Res, 1998, 7 Suppl 1:42-47.
[31] Frank MG. Sleep and synaptic plasticity in the developing and adult brain[J]. Curr Top Behav Neurosci, 2015, 25:123-149.
[32] Douma EH, de Kloet ER. Stress-induced plasticity and functioning of ventral tegmental dopamine neurons[J]. Neurosci Biobehav Rev, 2020, 108:48-77.

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