摘要： 探讨急性缺血性卒中患者血清超敏C-反应蛋白（hs-CRP）表达变化与改良TOAST 分型和OCSP 分型之间的关系。实验室检测显示，缺血性卒中组患者血清hs-CRP 表达水平高于正常对照组［（13.68 ± 6.92）mg/L 对（3.98 ± 0.76）mg/L；t = 6.922，P = 0.002］。TOAST 分型中以心源性栓塞型患者血清hs-CRP 水平［（16.82 ± 6.16）mg/L］最高，然后依次为动脉粥样硬化血栓形成型［（15.71 ± 5.68）mg/L］、不明病因型［（10.06 ± 3.89）mg/L］和小动脉型［（9.86 ± 3.75）mg/L，P = 0.027］；OCSP 分型由高至低分别为完全前循环梗死型［（17.02 ± 6.98）mg/L］、后循环梗死型［（15.91 ± 7.12）mg/L］、部分前循环梗死型［（12.83 ± 4.95）mg/L］和腔隙性梗死型［（10.61 ± 5.73）mg/L，P = 0.005］。提示急性缺血性卒中患者血清hs-CRP 表达水平在改良TOAST 分型和OCSP 分型各亚型中存在差异，可以此指导临床治疗和判断预后。

关键词: 卒中, C反应蛋白质

Abstract: This paper aims to investigate the relationship between serum high-sensitivity C-reactive protein (hs-CRP) level and modified TOAST classification as well as OCSP subtypes in patients with acute ischemic stroke. Serum hs-CRP was measured in 240 patients with acute ischemic stroke and 120 normal controls. All patients were classified according to modified TOAST classification and OCSP criteria. Serum hs-CRP levels in acute ischemic stroke group were significantly higher than those in normal control group [(13.68 ± 6.92) mg/L vs (3.98 ± 0.76) mg/L; t = 6.922, P = 0.002]. Among modified TOAST subtypes, the highest serum hs-CRP level was in cardioembolism (CE) group [(16.82 ± 6.16) mg/L], followed by arterothrombosis (AT) group [(15.17 ± 5.68) mg/L], stroke of undetermined etiology (SUD) group [(10.06 ± 3.89) mg/L] and small artery disease (SAD) group [(9.86 ± 3.75) mg/L, P = 0.027]. Among OCSP subtypes, the highest serum hs-CRP level was in total anterior circulation infarct (TACI) group [(17.02 ± 6.98) mg/L], followed by posterior circulation infarct (POCI) group [(15.91 ± 7.12) mg/L], partial anterior circulation infarct (PACI) group [(12.83 ± 4.95) mg/L] and lacunar infarct (LACI) group [(10.61 ± 5.73) mg/L, P = 0.005]. Serum hs-CRP levels are various in different modified TOAST and OCSP subtypes, which may reflect etiological and pathophysiological diversity of acute ischemic stroke, guide clinical treatment and help to predict prognosis.

Key words: Stroke, C-reactive protein