摘要： 探讨吉兰-巴雷综合征患者外周血Th17 细胞、血清和脑脊液IL-23 表达变化在其免疫发病机制中的作用。流式细胞术和酶联免疫吸附试验显示，吉兰-巴雷综合征组患者外周血Th17 细胞比例［（4.86 ± 0.60）%］和血清IL-23 水平［（111.80 ± 13.84）pg/ml］均高于对照组［（2.71 ± 0.54）%、（72.55 ±8.19）pg/ml］，差异有统计学意义（t = 2.616，P = 0.012；t = 2.300，P = 0.026）。吉兰-巴雷综合征组患者经静脉注射免疫球蛋白后，血清和脑脊液IL-23 水平恢复正常［（74.13 ± 6.18）和（72.92 ± 12.09）pg/ml］，与治疗前［（110.50 ± 15.66）和（102.30 ± 7.52）pg/ml］相比，差异具有统计学意义（t = 2.557，P = 0.022；t = 1.422，P = 0.046）。吉兰-巴雷综合征患者外周血Th17 细胞比例增加、血清和脑脊液IL-23 水平升高，提示二者可能参与吉兰-巴雷综合征的发生与发展。

关键词: 多发性神经根神经病, T 淋巴细胞, 辅助诱导, 白细胞介素23

Abstract: Guillain- Barré syndrome (GBS) is an acute autoimmune-mediated inflammatory neuropathy. In this paper, the percentage of Th17 in peripheral blood lymphocyte and the level of IL-23 in serum and cerebrospinal fluid (CSF) of patients with GBS were detected. Twenty-five patients with GBS and 20 controls were analyzed. The percentage of Th17 cells in patients with GBS was (4.86 ± 0.60)%, which was higher than that in controls [(2.71 ± 0.54)%; t = 2.616, P = 0.012]. Serum IL-23 increased in patients with GBS [(111.80 ± 13.84) pg/ml vs (72.55 ± 8.19) pg/ml; t = 2.300, P = 0.026]. The level of IL-23 in serum and CSF from patients with GBS before therapy [(110.50 ± 15.66) and (102.30 ± 7.52) pg/ml] declined to normal after therapy [(74.13 ± 6.18) and (72.92 ± 12.09) pg/ml], and the difference was statistically significant (t = 2.557, P = 0.022; t = 1.422, P = 0.046). Th17 cells and IL-23 increased in patients with GBS, indicating that they may involve in the pathogenesis of GBS.

Key words: Polyradiculoneuropathy, T-lymphocytes, helper-inducer, Interleukin-23