中国现代神经疾病杂志 ›› 2013, Vol. 13 ›› Issue (8): 723-725. doi: 10.3969/j.issn.1672-6731.2013.08.014

• 临床研究 • 上一篇    下一篇

2 血浆触珠蛋白与蛛网膜下隙出血后症状性脑血管痉挛关系的临床观察

毛群, 尉辉杰, 王焕宇, 佟小光, 范一木, 张建宁   

  1. 300060 天津市环湖医院神经外科[毛群(现在天津市第三医院神经外科,邮政编码:300250),王焕宇,佟小光,范一木];300052 天津医科大学总医院神经外科(尉辉杰,张建宁)
  • 出版日期:2013-08-25 发布日期:2013-08-04
  • 通讯作者: 张建宁 (Email:jianningzhang@hotmail.com)
  • 基金资助:

    国家自然科学基金资助项目( 项目编号:005CB522600);国家自然科学基金青年科学基金项目(项目编号:81200907);天津市应用基础及前沿技术研究计划青年基金资助项目(项目编号:12JCQNJC06800);天津市科技计划项目(项目编号:07KZ40)

Concentration of plasma haptoglobin and symptomatic cerebral vasospasm after subarachnoid hemorrhage

MAO Qun1, WEI Hui-jie2, WANG Huan-yu1, TONG Xiao-guang1, FAN Yi-mu1, ZHANG Jian-ning2   

  1. 1 Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin 300060, China
    2 Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China
  • Online:2013-08-25 Published:2013-08-04
  • Contact: ZHANG Jian-ning (Email: jianningzhang@hotmail.com)
  • Supported by:

    This study was supported by the National Natural Science Foundation of China (No. 005CB522600), Program of National Natural Science Foundation for Young Scientists (No. 81200907), Tianjin Basic Research and Research in Cutting-edge Technology Planning Fund for Young Scientist (No. 12JCQNJC06800) and Tianjin Science and Technology Program (No. 07KZ40).

摘要: 探讨蛛网膜下隙出血患者血浆触珠蛋白表达变化与症状性脑血管痉挛间的关系。共观察43 例自发性蛛网膜下隙出血患者,其中19 例于发病后3 ~ 14 天出现症状性脑血管痉挛,酶联免疫吸附试验显示血浆触珠蛋白水平[(0.29 ± 0.14)g/L]低于24 例无症状性脑血管痉挛患者[(0.78 ± 0.48)g/L],差异有统计学意义(t = 4.848,P = 0.000)。提示蛛网膜下隙出血后血浆触珠蛋白水平降低可能与症状性脑血管痉挛发生有关。

关键词: 触珠蛋白类, 蛛网膜下腔出血, 脑缺血发作, 短暂性

Abstract: The relation of plasma haptoglobin concentration to symptomatic cerebral vasospasm (SCVS) after subarachnoid hemorrhage (SAH) was investigated. The plasma concentration of haptoglobin was analyzed by enzyme-linked immunosorbent assay (ELISA). SCVS was determined by aggravated headache, deteriorated conscious state a few days after ictus or by new neurologic impairment and new ischemic injuries on repeated CT scans. The mean concentration of plasma haptoglobin in 19 patients with SCVS was (0.29 ± 0.14) g/L, whereas it was (0.78 ± 0.48) g/L in 24 patients without SCVS. These findings may suggest that plasma haptoglobin concentration seems to be associated with the development of SCVS after SAH.

Key words: Haptoglobins, Subarachnoid hemorrhage, Ischemic attack, transient