摘要： 探讨蛛网膜下隙出血患者血浆触珠蛋白表达变化与症状性脑血管痉挛间的关系。共观察43 例自发性蛛网膜下隙出血患者，其中19 例于发病后3 ~ 14 天出现症状性脑血管痉挛，酶联免疫吸附试验显示血浆触珠蛋白水平［（0.29 ± 0.14）g/L］低于24 例无症状性脑血管痉挛患者［（0.78 ± 0.48）g/L］，差异有统计学意义（t = 4.848，P = 0.000）。提示蛛网膜下隙出血后血浆触珠蛋白水平降低可能与症状性脑血管痉挛发生有关。
关键词:
触珠蛋白类,
蛛网膜下腔出血,
脑缺血发作,
短暂性
Abstract: The relation of plasma haptoglobin concentration to symptomatic cerebral vasospasm (SCVS) after subarachnoid hemorrhage (SAH) was investigated. The plasma concentration of haptoglobin was analyzed by enzyme-linked immunosorbent assay (ELISA). SCVS was determined by aggravated headache, deteriorated conscious state a few days after ictus or by new neurologic impairment and new ischemic injuries on repeated CT scans. The mean concentration of plasma haptoglobin in 19 patients with SCVS was (0.29 ± 0.14) g/L, whereas it was (0.78 ± 0.48) g/L in 24 patients without SCVS. These findings may suggest that plasma haptoglobin concentration seems to be associated with the development of SCVS after SAH.
Key words:
Haptoglobins,
Subarachnoid hemorrhage,
Ischemic attack, transient
毛群, 尉辉杰, 王焕宇, 佟小光, 范一木, 张建宁. 血浆触珠蛋白与蛛网膜下隙出血后症状性脑血管痉挛关系的临床观察[J]. 中国现代神经疾病杂志, 2013, 13(8): 723-725.
MAO Qun, WEI Hui-jie, WANG Huan-yu, TONG Xiao-guang, FAN Yi-mu, ZHANG Jian-ning. Concentration of plasma haptoglobin and symptomatic cerebral vasospasm after subarachnoid hemorrhage[J]. Chinese Journal of Contemporary Neurology and Neurosurgery, 2013, 13(8): 723-725.