Progress on the role of mitophagy in myocardial ischemia-reperfusion injury

doi:10.16352/j.issn.1001-6325.2023.11.1723

Abstract

Abstract: Myocardial ischemia-reperfusion injury (MI/RI) is potentially associated with activation of mitophagy through a variety of molecular mechanisms. Moderate mitophagy is effective in maintaining mitochondrial membrane potential and cell membrane structure and function, thereby reducing MI/RI, whereas mitochondrial dysfunction, inadequate clearance or over-activated mitophagy can make MI/RI more severe.

Key words: mitophagy, myocardial ischemia-reperfusion injury (MI/RI), molecular mechanisms, signaling pathway

CLC Number:

MA Congcong, LIU Yang, LYU Yang, WANG Haiping. Progress on the role of mitophagy in myocardial ischemia-reperfusion injury[J]. Basic & Clinical Medicine, 2023, 43(11): 1723-1727.

References 27

[1]	Zhou M, Yu Y, Luo X, et al. Myocardial ischemia-reperfusion injury: therapeutics from a mitochondria-centric perspective[J]. Cardiology, 2021;146:781-792.
[2]	Chen Y, Lin H, Wang Q, et al. Protective role of silibinin against myocardial ischemia/reperfusion injury-induced cardiac dysfunction[J]. Int J Biol Sci, 2020, 16: 1972-1988.
[3]	Zhang D, Zheng N, Fu X, et al. Dl-3-n-butylphthalide attenuates myocardial ischemia reperfusion injury by suppressing oxidative stress and regulating cardiac mitophagy via the PINK1/Parkin pathway in rats[J]. J Thorac Dis, 2022, 14: 1651-1662.
[4]	Zhu N, Li J, Li Y, et al. Berberine protects against simulated ischemia/reperfusion injury-induced H9C2 cardiomyocytes apoptosis in vitro and myocardial ischemia/reperfusion-induced apoptosis in vivo by regulating the mitophagy-mediated HIF-1alpha/BNIP3 pathway[J]. Front Pharmacol, 2020, 11: 367-378.
[5]	Bravo-San J, Kroemer G, Galluzzi L. Autophagy and mitophagy in cardiovascular disease[J]. Circ Res, 2017;120:1812-1824.
[6]	Quiles J, Gustafsson A. Mitochondrial quality control and cellular proteostasis: two sides of the same coin[J]. Front Physiol, 2020, 11: 515-531.
[7]	Choi G, Lee H, Chae C, et al. BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects[J]. Nat Commun, 2021;12:487-505.
[8]	Bonora M, Wieckowski M, Sinclair D, et al. Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles[J]. Nat Rev Cardiol, 2019, 16: 33-55.
[9]	Xiong W, Hua J, Liu Z, et al. PTEN induced putative kinase 1 (PINK1) alleviates angiotensin II-induced cardiac injury by ameliorating mitochondrial dysfunction[J]. Int J Cardiol, 2018, 266: 198-205.
[10]	Tu M, Tan V, Yu J, et al. RhoA signaling increases mitophagy and protects cardiomyocytes against ischemia by stabilizing PINK1 protein and recruiting Parkin to mitochondria[J]. Cell Death Differ, 2022, 29: 2472-2486.
[11]	Luo H, Zhang R, Krigman J, et al. A healthy heart and a healthy brain: looking at mitophagy[J]. Front Cell Dev Biol, 2020, 8: 294-305.
[12]	Yao J, Wang J, Xu Y, et al. CDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the thera-peutic effects involving mitochondrial dysfunction in hepatocellular carcinoma[J]. Autophagy, 2022, 18: 1879-1897.
[13]	Gao A, Jiang J, Xie F, et al. Bnip3 in mitophagy: novel insights and potential therapeutic target for diseases of secondary mitochondrial dysfunction[J]. Clinica Chimica Acta, 2020, 506: 72-83.
[14]	Rogov V, Suzuki H, Marinković M, et al. Phosphoryla-tion of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins[J]. Sci Rep, 2017, 7: 1131-1143.
[15]	Chen M, Chen Z, Wang Y, et al. Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy[J]. Autophagy, 2016, 12: 689-702.
[16]	Wang C, Li Y, Li Y, et al. FAM134B-mediated ER-phagy in Mg2+-free solution-induced mitochondrial calcium homeostasis and cell death in epileptic hippocampal neurons[J]. Neurochem Res, 2021, 46: 2485-2494.
[17]	Ajoolabady A, Chiong M, Lavandero S, et al. Mitophagy in cardiovascular diseases: molecular mechanisms, pathogenesis, and treatment[J]. Trends Mol Med, 2022;28:836-849.
[18]	Mukherjee I, Ghosh M, Meinecke M. MICOS and the mitochondrial inner membrane morphology-when things get out of shape[J]. FEBS Lett, 2021, 595: 1159-1183.
[19]	Wang X, An P, Gu Z, et al. Mitochondrial metal ion transport in cell metabolism and disease[J]. Int J Mol Sci, 2021, 22:7525-7542.
[20]	江罗佳,许海波.白藜芦醇缓解低氧/复氧诱导的TCMK1细胞线粒体自噬[J].基础医学与临床,2022,42:1709-1715.
[21]	Lieder H, Braczko F, Gedik N, et al. Cardioprotection by post-conditioning with exogenous triiodothyronine in isola-ted perfused rat hearts and isolated adult rat cardiomy-ocytes[J]. Basic Res Cardiol, 2021,116:27-42.
[22]	孙宏, 刘凯, 蔡国锋,等. 基于线粒体自噬探讨白金方对MIRI大鼠的心肌保护作用及机制[J]. 时珍国医国药, 2020, 31: 539-542.
[23]	李宏玉, 尹侠, 王艳霞, 等. 运动预处理对心肌缺血再灌注损伤老龄大鼠心肌细胞自噬和凋亡的影响[J]. 康复学报, 2022, 32: 124-130.
[24]	张小赏, 童随阳, 操传斌. 紫苏醛对大鼠心肌缺血/再灌注损伤诱导的自噬的影响[J]. 湖北医药学院学报, 2022, 41: 224-228.
[25]	肖钰雪, 史晓梅, 谢璐璐,等. 乌头赤石脂丸对大鼠心肌缺血再灌注损伤自噬及PI3K/Akt/GSK-3β信号通路的影响[J]. 中国实验方剂学杂志, 2022, 28: 26-32.
[26]	Yang F, Li T, Dong Z, et al. MicroRNA-410 is involved in mitophagy after cardiac ischemia/reperfusion injury by targeting high-mobility group box 1 protein[J]. J Cell Biochem, 2018, 119: 2427-2439.
[27]	He L, Zhou Q, Huang Z, et al. PINK1/Parkin-mediated mitophagy promotes apelin-13-induced vascular smooth muscle cell proliferation by AMPKalpha and exacerbates atherosclerotic lesions[J]. J Cell Physiol, 2019, 234: 8668-8682.