Research progress on mitophagy in the development and treatment of osteosarcoma

doi:10.16352/j.issn.1001-6325.2025.10.1377

Abstract

Abstract: Mitophagy, as a highly conserved cellular defense mechanism, precisely recognizes and eliminates dysfunctional or excessive mitochondria, thereby maintaining homeostasis of the mitochondrial network and providing a stable energy supply and raw materials for biosynthesis in cells. Mitophagy exerts regulatory effects on the development of osteosarcoma through multiple molecular mechanisms. Targeting this mechanism as a new strategy for therapeutic intervention provides a solid theoretical foundation and set stage for exploring novel targeted therapies, thereby driving the field of osteosarcoma treatment towards more precise and efficient directions.

Key words: osteosarcoma, mitophagy, cellular autophagy, metabolic reprogramming, signaling pathway

CLC Number:

R738.1

NING Kangsheng, YUN Chao, LI Yi, Morigele. Research progress on mitophagy in the development and treatment of osteosarcoma[J]. Basic & Clinical Medicine, 2025, 45(10): 1377-1381.

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