Abstract: The gastrointerstinal micobiota is a large and complex microecosystem, which is influenced by heredity, diet, drug and environmental factors. Helicobacter pylori (Hp) is an important pathogenic factor of chronic gastritis, peptic ulcer and gastric cancer and other diseases. It can provide a novel thought for Hp pathogenesis to illustrate the interaction between Hp and other flora in gastrointestinal tract and its effect on the development of Hp-related diseases.

Key words: gastrointestinal, microbiota, Helicobacter pylori, gastric cancer