Abstract: Sox5 gene is located on 12p12.1, containing 29 exons, it can transcript 5 variants, thus produce 5 isoforms. L-SOX5A is an isoform relative extensive studied, its functions include regulate embryonic development, and determine cell differentiation. Sox5 was implicated in prostate cancer, breast cancer and lymphoma.

Key words: Sox family, Sox5, cell differentiation, tumor metastasis