Abstract: Exosome is a kind of functional vesicles secreted to the extracellular matrix. The role of glioma exosomes in the development, diagnosis and treatment of glioma is increasingly recognized. This review aims to summarize the most common biomarkers of glioma exosomes and the applications of exosomes in treatments, which mainly includes mediating immune therapy, anti-tumor therapeutic vehicles, and intervention of intercellular communications between tumor cells.

Key words: glioma, exosomes, biomarkers, liquid biopsy