Abstract: TFEB could induced by autophagic regulatory factors, such as mTOR and cellular stresses. TFEB could media the translation of peroxisome proliferator-activated receptor gamma coactivator 1-alpha(PPAR α), peroxisome proliferator-activated receptor γ coactivator 1 α(PGC-1α) and autophagy, lysosomal synthesis related genes, then regulat lipid metabolism and the release inflammatory cytokine. AS a novel Mechanism, TFEB could regulate Lipid metabolism in order to restrain the progression of atherosclerosis and promote to plaque stabilization.

Key words: TFEB , atherosclerosis, autophagy, PPAR α, PGC-1α