Abstract: The receptor tyrosine kinase (RTK) AXL is over expressed in multiple tumor cells and mediates the metastasis and drug resistance of tumor cells through a variety of signaling pathways, especially form positive feedback loops with EMT, therefore has become a new tumor therapeutic target. By inhibiting the expression of AXL can effectively reverse EMT and tumor metastasis and drug-resistance.

Key words: Key words: AXL, cancer cell, metastasis, invasion, drug resistance