Abstract: Somatostatin analogs are the mainstay of medical therapy for growth hormone-secreting pituitary adenomas. They can inhibit the growth hormone secretion in pituitary gland and the proliferation of tumor cells. However, some patients get unsatisfying curative effect because of drug resistance. The mechanisms of somatostatin analog resistance mainly are related to somatostatin receptor, downstream signaling pathways, histopathology, adhesion molecule and other factors.

Key words: growth hormone-secreting pituitary adenomas, acromegaly, somatostatin analog, resistance