Basic & Clinical Medicine ›› 2025, Vol. 45 ›› Issue (9): 1132-1138.doi: 10.16352/j.issn.1001-6325.2025.09.1132
Previous Articles Next Articles
WANG Yangyang, LIU Yang, ZHAO Han, WANG Wei*
Received:2025-02-27
Revised:2025-06-27
Online:2025-09-05
Published:2025-08-27
Contact:
*wangwei4596@pumch.cn
CLC Number:
WANG Yangyang, LIU Yang, ZHAO Han, WANG Wei. Current applications and implications of Comprehensive Geriatric Assessment in elderly cancer patients[J]. Basic & Clinical Medicine, 2025, 45(9): 1132-1138.
| [1] | 中国抗癌协会. 《中国恶性肿瘤学科发展报告(2023)》——老年肿瘤研究进展篇[EB/OL]. [2024-12-25]. http://www.caca.org.cn/system/2024/04/30/030090675.shtml. |
| [2] | Dale W, Klepin HD, Williams GR, et al. Practical assessment and management of vulnerabilities in older patients receiving systemic cancer therapy: ASCO guideline update[J].J Clin Oncol, 2023,41:4293-4312. doi:10.1200/JCO.23.00933. |
| [3] | Puts M, Strohschein F, Oldenmenger W, et al. Position statement on oncology and cancer nursing care for older adults with cancer and their caregivers of the International Society of Geriatric Oncology Nursing and Allied Health Interest Group, the Canadian Association of Nurses in Oncology Oncology & Aging Special Interest Group, and the European Oncology Nursing Society[J]. J Geriatr Oncol, 2021,12:1000-1004. doi:10.1016/j.jgo.2021.03.010. |
| [4] | Mohile SG, Mohamed MR, Xu H, et al. Evaluation of geriatric assessment and management on the toxic effects of cancer treatment (GAP70+): a cluster-randomised study[J]. Lancet, 2021,398:1894-1904. doi:10.1016/S0140-6736(21)01789-X. |
| [5] | Li D, Sun CL, Kim H, et al. Geriatric assessment-driven intervention (GAIN) on chemotherapy-related toxic effects in older adults with cancer: a randomized clinical trial[J]. JAMA Oncol, 2021,7:e214158. doi:10.1001/jamaoncol.2021.4158. |
| [6] | Loh KP, Liposits G, Arora SP, et al. Adequate assessment yields appropriate care—the role of geriatric assessment and management in older adults with cancer: a position paper from the ESMO/SIOG Cancer in the Elderly Working Group[J]. ESMO Open, 2024,9:103657. doi:10.1016/j.esmoop.2024.103657. |
| [7] | Dotan E, Walter LC, Browner IS, et al. NCCN guidelines(R) insights: older adult oncology, version 1.2023[J]. J Natl Compr Canc Netw, 2023,19:1006-1019. doi:10.6004/jnccn.2021.0043. |
| [8] | Hamaker M, Lund C, Te Molder M, et al. Geriatric assessment in the management of older patients with cancer- a systematic review (update)[J]. J Geriatr Oncol, 2022,13:761-777. doi:10.1016/j.jgo.2022.04.008. |
| [9] | Chuang MH, Chen JY, Tsai WW, et al. Impact of comprehensive geriatric assessment on the risk of adverse events in the older patients receiving anti-cancer therapy: a systematic review and meta-analysis[J]. Age Ageing, 2022,51: afac145. doi:10.1093/ageing/afac145. |
| [10] | Disalvo D, Moth E, Soo WK, et al. The effect of comprehensive geriatric assessment on care received, treatment completion, toxicity, cancer-related and geriatric assessment outcomes, and quality of life for older adults receiving systemic anti-cancer treatment: a systematic review[J]. J Geriatr Oncol, 2023,14:101585. doi:10.1016/j.jgo.2023.101585. |
| [11] | Gregersen M, Jensen K, Orum M. The impact of multidisciplinary geriatric follow-up on quality of life in older, non-surgical prefrail and frail patients with cancer a randomized controlled trial[J]. J Geriatr Oncol, 2024,15:102069. doi:10.1016/j.jgo.2024.102069. |
| [12] | Giger AW, Ditzel HM, Ewertz M, et al. Effect of comprehensive geriatric assessment on hospitalizations in older adults with frailty initiating curatively intended oncologic treatment: the PROGNOSIS-RCT study[J]. J Geriatr Oncol, 2024,15:101821. doi:10.1016/j.jgo.2024.101821. |
| [13] | Alibhai SMH, Alam Z, Saluja R, et al. Economic evaluation of a geriatric oncology clinic[J]. Cancers (Basel), 2022,14:789-800. doi:10.3390/cancers14030789. |
| [14] | McKenzie GAG, Johnson MJ, Lind MJ, et al. Geriatric assessment prior to cancer treatment: a health economic evaluation[J]. J Geriatr Oncol, 2023,14:101504. doi:10.1016/j.jgo.2023.101504. |
| [15] | Sahakyan Y, Li Q, Alibhai SMH, et al. Cost-utility analysis of geriatric assessment and management in older adults with cancer: economic evaluation within 5C trial[J]. J Clin Oncol, 2024,42:59-69. doi:10.1200/JCO.23.00930. |
| [16] | Dale W, Williams GR, R MacKenzie A, et al. How is geriatric assessment used in clinical practice for older adults with cancer? A survey of cancer providers by the American Society of Clinical Oncology[J]. JCO Oncol Pract, 2021,17:336-344. doi:10.1200/OP.20.00442. |
| [17] | Sattar S, Haase KR, Puts M, et al. Oncology care providers′ perceptions and anticipated barriers regarding the use of geriatric assessment in routine clinic practice: a mixed-methods study[J]. J Geriatr Oncol, 2024,15:101768. doi:10.1016/j.jgo.2024.101768. |
| [18] | Nishijima TF, Tamura K. Geriatric Oncology Guideline-establishing (GOGGLE) Study Group. Landscape of education and clinical practice in geriatric oncology: a Japanese nationwide survey[J]. Jpn J Clin Oncol, 2019,49:1114-1119. doi:10.1093/jjco/hyz123. |
| [19] | Mizutani T, Cheung KL, Hakobyan Y, et al. Leave no one behind: A global survey of the current state of geriatric oncology practice by SIOG national representa-tives[J]. J Geriatr Oncol, 2024,15:101709. doi:10.1016/j.jgo.2024.101709. |
| [20] | Gajra A, Jeune-Smith Y, Fortier S, et al. The use and knowledge of validated geriatric assessment instruments among US community oncologists[J]. JCO Oncol Pract, 2022,18:e1081-e1090. doi:10.1200/OP.21.00743. |
| [21] | Matsuoka A, Mizutani T, Kaji Y, et al. Barriers and facilitators to implementing geriatric assessment in daily oncology practice in Japan: a qualitative study using an implementation framework[J]. J Geriatr Oncol, 2023,14:101625. doi:10.1016/j.jgo.2023.101625. |
| [22] | 林燕,宋雨,徐颖,等. 简化老年综合评估分级在老年女性乳腺癌患者中的应用价值[J]. 中国医学科学院学报, 2021,43:395-401. doi:10.3881/j.issn.1000-503X.13752. |
| [23] | Uranga C, Chien LC, Liposits G. Geriatric screening in older adults with cancer-a Young International Society of Geriatric Oncology and Nursing & Allied Health Interest Group initiative[J]. J Geriatr Oncol, 2022,13:374-377. doi:10.1016/j.jgo.2021.09.003. |
| [24] | Diaz FC, Hamparsumian A, Loh KP, et al. Geriatric oncology: a 5-year strategic plan[J]. Am Soc Clin Oncol Educ Book, 2024,44:e100044. doi:10.1200/EDBK_100044. |
| [25] | Zhang Q, Wang L, Zhang S, et al. Cross-cultural adaptation and validation of the geriatric 8 screening tool in Chinese hospitalized older adults with cancer[J]. Geriatr Nurs, 2023,49:22-29. doi:10.1016/j.gerinurse.2022.10.021. |
| [26] | van Walree IC, Vondeling AM, Vink GR, et al. Development of a self-reported version of the G8 screening tool[J]. J Geriatr Oncol, 2019,10:926-930. doi:10.1016/j.jgo.2019.08.011. |
| [27] | Chon J, Timilshina N, AlMugbel F, et al. Validity of a self-administered G8 screening test for older patients with cancer[J]. J Geriatr Oncol, 2023,14:101553. doi:10.1016/j.jgo.2023.101553. |
| [28] | McKenzie GAG, Bullock AF, Greenley SL, et al. Implementation of geriatric assessment in oncology settings: a systematic realist review[J]. J Geriatr Oncol, 2021,12:22-33. doi:10.1016/j.jgo.2020.07.003. |
| [29] | Hamaker ME, Wildiers H, Ardito V, et al. Study protocol for two stepped-wedge interventional trials evaluating the effects of holistic information technology-based patient-oriented management in older multimorbid patients with cancer: the GERONTE trials[J]. J Geriatr Oncol, 2024,15:101761. doi:10.1016/j.jgo.2024.101761. |
| [30] | Kenis C, Heeren P, Decoster L, et al. A Belgian survey on geriatric assessment in oncology focusing on large-scale implementation and related barriers and facilitators[J]. J Nutr Health Aging, 2016,20:60-70. doi:10.1007/s12603-016-0677-2. |
| [31] | Dale W. Why is geriatric assessment so infrequently used in oncology practices? The ongoing issue of nonadherence to this standard of care for older adults with cancer[J]. JCO Oncol Pract, 2022,18:475-477. doi:10.1200/OP.22.00197. |
| [32] | Nightingale G, Burhenn PS, Puts M, et al. Integrating nurses and allied health professionals in the care of older adults with cancer: a report from the International Society of Geriatric Oncology Nursing and Allied Health Interest Group[J]. J Geriatr Oncol, 2020,11:187-190. doi:10.1016/j.jgo.2019.06.012. |
| [33] | Javier-González M, Boulahssass R, Lago LD, et al. Survey on current clinical practice in geriatric oncology: the individual experience in five European cancer centers[J]. Eur Geriatr Med. 2025,16:125-133. doi:10.1007/s41999-024-01041-7. |
| [34] | Puts MTE, Strohschein FJ, Del Giudice ME, et al. Role of the geriatrician, primary care practitioner, nurses, and collaboration with oncologists during cancer treatment delivery for older adults: a narrative review of the literature[J]. J Geriatr Oncol, 2018,9:398-404. doi:10.1016/j.jgo.2018.04.008. |
| [35] | Presley CJ, Krok-Schoen JL, Wall SA, et al. Implement-ing a multidisciplinary approach for older adults with Cancer: geriatric oncology in practice[J]. BMC Geriatr, 2020,20:231-240. doi:10.1186/s12877-020-01625-5. |
| [36] | Ho F, Kow A, Lim WC, et al. Feasibility of a geriatric oncology longitudinal end to end (GOLDEN) program in a tertiary cancer center in Singapore[J]. Oncologist, 2023,28:e198-e204. doi:10.1093/oncolo/oyac276. |
| [37] | Alemania E, Hind A, Samara J, et al. Nurse-led interventions among older adults affected by cancer: an integrative review[J]. Asia Pac J Oncol Nurs, 2023,10: 100289. doi:10.1016/j.apjon.2023.100289. |
| [38] | Gomes F, Farrington N, Pearce J, et al. The care of older patients with cancer across the United Kingdom in 2024: a narrative review by the International Society of Geriatric Oncology UK Country Group[J]. J Geriatr Oncol, 2025,16:102133. doi:10.1016/j.jgo.2024.102133. |
| [39] | Overcash J, Ford N, Kress E, et al. Comprehensive geriatric assessment as a versatile tool to enhance the care of the older person diagnosed with cancer[J]. Geriatrics (Basel), 2019,4:39-51. doi:10.3390/geriatrics4020039. |
| [40] | Festen S, van der Wal-Huisman H, van der Leest AHD, et al. The effect of treatment modifications by an onco-geriatric MDT on one-year mortality, days spent at home and postoperative complications[J]. J Geriatr Oncol, 2021,12:779-785. doi:10.1016/j.jgo.2020.12.003. |
| [41] | Kang S, Allen S, Brown A, et al. Providing early access to geriatric oncology services in a regional cancer centre- a two-year experience in the establishment of a geriatric oncology nurse navigator model[J]. J Geriatr Oncol, 2025,16:102145. doi:10.1016/j.jgo.2024.102145. |
| [42] | 申红霞,严斯静,黎敏仪,等.实施科学中实施策略的介绍[J].中国循证医学杂志, 2023,23:708-714. doi:10.7507/1672-2531.202211027. |
| [1] | WANG Qiumei, LI Xiaoyuan, KANG Lin, SUN Xiaohong, LI Hailong, DUAN Yanping, LIU Ying, GUAN Mei, ZHAO Lin. Consensus recommendation on Comprehensive Geriatric Assessment for elderly cancer patients from Peking Union Medical College Hospital [J]. Basic & Clinical Medicine, 2025, 45(9): 1122-1131. |
| [2] | KANG Lei, ZHU Junlan. Molecular mechanisms of selenium binding protein 1 expression regulation in cancer cells [J]. Basic & Clinical Medicine, 2025, 45(9): 1224-1228. |
| [3] | WEI Xinwen, WEN Xiaojun, FAN Zhaoqiang, LAO Xifeng, ZHANG Luqing, ZHONG Ming. CircAPLP2 inhibits proliferation, migration and invasion of human colorectal cancer cell lines through regulating miR-455-3p/STMN1 axis [J]. Basic & Clinical Medicine, 2025, 45(9): 1208-1214. |
| [4] | AN Xin, JIA Lin, Mawusumu·MAMUT, HUANG Zhipeng, KahrimanI·SLAM, Rexiati·REHEMAN, Hairila·WULAMU, Kerbanjiang·ABULIKIM, Jesur·BATUR. Effects of ANGPT1 on proliferation,invasion and angiogenesis of mouse prostate cancer cell line RM-1 [J]. Basic & Clinical Medicine, 2025, 45(9): 1165-1172. |
| [5] | CHEN Lingyun, CHEN Wensong, SUN Qinqiang, ZI Jin. Progress in urinary metabolomics research technologies and applications in cancer diagnosis [J]. Basic & Clinical Medicine, 2025, 45(8): 999-1009. |
| [6] | ZOU Qingbo, ZHANG Guochen, PAN Changjing. Gypenoside inhibits the proliferation, migration and invasion of prostate cancer cell line PC-3 [J]. Basic & Clinical Medicine, 2025, 45(8): 1059-1065. |
| [7] | HUANG Qianqian, JIA Yufang, YU Huajun,CHEN Rongrong,CHEN Lili, WU Jun, ZHANG Haitao. Stable knockout of ACSS3 in lung cancer cell line using CRISPR/Cas 9 technology [J]. Basic & Clinical Medicine, 2025, 45(8): 1016-1021. |
| [8] | JIA Chunliang, LIANG Lei, LI Hansong, WANG Jian, ZHANG Lei, LI Qingke, YAO Yuan. Scutellarin inhibits proliferation and migration of human gastric cancer cell line MGC803 [J]. Basic & Clinical Medicine, 2025, 45(8): 1048-1053. |
| [9] | WU Haifeng, LI Xiaolong, LI Fang, CHEN Xiaohua, SONG Rui, HAN Xue. Expression of KIF23 in rectal cancer tissues is correlated with prognosis [J]. Basic & Clinical Medicine, 2025, 45(8): 1054-1058. |
| [10] | TIAN Ye, HE Quan, WANG Xiaojuan. RPRD1B is highly expressed in human ovarian cancer cell lines and promotes tumor cell proliferation [J]. Basic & Clinical Medicine, 2025, 45(8): 1066-1072. |
| [11] | CHEN Lei,REN Weihao,WANG Lide. Knockdown of translocase of inner mitochondrial membrane 8A enhances gefitinib sensitivity to lung cancer cell line PC-9 [J]. Basic & Clinical Medicine, 2025, 45(8): 1073-1077. |
| [12] | YANG Rui, DU Sifen, JIANG Lehui, FU Tian, REN Pengju, JIANG Chengyu, ZHANG Yanli. Network pharmacology-based screening and validation of tea-derived small molecules against lung cancer [J]. Basic & Clinical Medicine, 2025, 45(7): 939-946. |
| [13] | SUN Ting, ZOU Teng, YANG Yisong, LIU Shuangping, REN Xin, WANG Dan. Inhibitory effect of β-elemonic acid on proliferation and invasion of colon cancer cell lines [J]. Basic & Clinical Medicine, 2025, 45(6): 748-754. |
| [14] | JIN Xiaoxia, LIU Yushan, HU Jiping, ZHU Xinghua. Expression of COA6 in breast cancer and its correlation with tumor immune cell infiltration [J]. Basic & Clinical Medicine, 2025, 45(6): 755-761. |
| [15] | QIU Yuchong, DU Wenjing. Malic enzyme 2 promotes liver cancer progression by regulating SHCBP1 [J]. Basic & Clinical Medicine, 2025, 45(6): 741-747. |
| Viewed | ||||||
|
Full text |
|
|||||
|
Abstract |
|
|||||