Abstract: Obesity can promote asthma exacerbations by a complex mechanism of action involving multi-system interactions such as mechanomechanics, inflammatory response, genetic inheritance, microbial composition and metabolic syndrome. Obesity reduces the compliance of lung tissue and chest wall, increases airway resistance, leads to airway narrowing, and aggravates asthma symptoms. Obesity can increase the release of inflammatory factors and aggravate the airway inflammatory response in asthma. Obesity can increase the risk of asthma by genetically influencing the obesity phenotype. Obesity can affect the development of asthma by altering the composition of the microbiota. Obesity can also worsen asthma by causing a series of metabolic syndrome. In conclusion,the mechanisms associated with obesity-promoted asthma involve multi-system interactions. Targeted metabolic drugs and biologics also show great potential in the treatment of obesity-associated asthma.

Key words: asthma, obesity, mechanisms, treatment