Progress on the role of N-acetyltransferase 10 in tumor development

doi:10.16352/j.issn.1001-6325.2024.11.1589

Abstract

Abstract: N-acetyltransferase10(NAT10) is a protein widely expressed in a variety of tissues and cells. The high expression of NAT10 is closely related to tumor invasion, metastasis and drug resistance. The mechanism of NAT10 promoting tumor genesis and development involves the regulation of cell cycle, mRNA stability, translation efficiency and related pathways due to the changes in the expression or location of NAT10, thus affecting the occurrence, development and prognosis of tumors.

Key words: N-acetyltransferase10, N4-acetylcytidine, tumor

CLC Number:

R731-31

GU Zhongjia, LAI Siying, CHEN Dunjin, DU Lili. Progress on the role of N-acetyltransferase 10 in tumor development[J]. Basic & Clinical Medicine, 2024, 44(11): 1589-1593.

References

[1] Arango D, Sturgill D, Alhusaini N, et al. Acetylation of cytidine in mRNA promotes translation efficiency[J]. Cell,2018,175. doi: 10.1016/j.cell.2018.10.030.
[2] Liu HY, Liu YY, Zhang YL, et al. Poly(ADP-ribosyl)ation of acetyltransferase NAT10 by PARP1 is required for its nucleoplasmic translocation and function in response to DNA damage[J]. Cell Commun Signal,2022,20:127. doi: 10.1186/s12964-022-00932-1.
[3] Zhang X, Liu J, Yan S, et al. High expression of N-acetyltransferase 10: a novel independent prognostic marker of worse outcome in patients with hepatocellular carcinoma[J]. Int J Clin Exp Pathol,2015,8:14765-14771.
[4] Ma R, Chen J, Jiang S, et al. Up regulation of NAT10 promotes metastasis of hepatocellular carcinoma cells through epithelial-to-mesenchymal transition[J]. Am J Transl Res,2016,8:4215-4223.
[5] Pan Z, Bao Y, Hu M, et al. Role of NAT10-mediated ac4C-modified HSP90AA1 RNA acetylation in ER stress-mediated metastasis and lenvatinib resistance in hepatocellular carcinoma[J]. Cell Death Discov,2023,9:56. doi: 10.1038/s41420-023-01355-8.
[6] Zhang Y, Jing Y, Wang Y, et al. NAT10 promotes gastric cancer metastasis via N4-acetylated COL5A1[J]. Signal Transduct Target Ther,2021,6:173. doi: 10.1038/s41392-021-00489-4.
[7] Wu Y, Cao Y, Liu H, et al. Remodelin, an inhibitor of NAT10, could suppress hypoxia-induced or constitutional expression of HIFs in cells[J]. Mol Cell Biochem,2020,472:19-31. doi: 10.1007/s11010-020-03776-w.
[8] Deng M, Zhang L, Zheng W, et al. Helicobacter pylori-induced NAT10 stabilizes MDM2 mRNA via RNA acetylation to facilitate gastric cancer progression[J]. J Exp Clin Cancer Res,2023,42:9. doi: 10.1186/s13046-022-02586-w.
[9] Feng Z, Li K, Qin K, et al. The LINC00623/NAT10 signaling axis promotes pancreatic cancer progression by remodeling ac4C modification of mRNA[J]. J Hematol Oncol,2022,15:112. doi: 10.1186/s13045-022-01338-9.
[10] Xu D, Huang K, Chen Y, et al. Immune response and drug therapy based on ac4C-modified gene in pancreatic cancer typing[J]. Front Immunol,2023,14:1133166. doi: 10.3389/fimmu.2023.1133166.
[11] Jin C, Wang T, Zhang D, et al. Acetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac4C acetylation of KIF23 mRNA[J]. J Exp Clin Cancer Res,2022,41:345. doi: 10.1186/s13046-022-02551-7.
[12] Zheng X, Wang Q, Zhou Y, et al. N-acetyltransferase 10 promotes colon cancer progression by inhibiting ferroptosis through N4-acetylation and stabilization of ferroptosis suppressor protein 1 (FSP1) mRNA[J]. Cancer Commun,2022,42:1347-1366. doi: 10.1002/cac2.12363.
[13] Zhang Y, Deng Z, Sun S, et al. NAT10 acetylates BCL-XL mRNA to promote the proliferation of multiple myeloma cells through PI3K-AKT pathway[J]. Front Oncol,2022,12:967811. doi: 10.3389/fonc.2022.967811.
[14] Wei R, Cui X, Min J, et al. NAT10 promotes cell proliferation by acetylating CEP170 mRNA to enhance translation efficiency in multiple myeloma[J]. Acta Pharmaceutica Sinica B,2022,12:3313-3325. doi: 10.1016/j.apsb.2022.01.015.
[15] Zheng J, Tan Y, Liu X, et al. NAT10 regulates mitotic cell fate by acetylating Eg5 to control bipolar spindle assembly and chromosome segregation[J]. Cell Death Differ,2022,29:846-860. doi: 10.1038/s41418-021-00899-5.
[16] Wang G, Zhang M, Zhang Y, et al. NAT10-mediated mRNA N4-acetylcytidine modification promotes bladder cancer progression[J]. Clin Transl Med,2022,12:e738. doi: 10.1002/ctm2.738.
[17] Xie R, Cheng L, Huang M, et al. NAT10 drives cisplatin chemoresistance by enhancing ac4C-associated DNA repair in bladder cancer[J]. Cancer Res,2023,83:1666-1683. doi: 10.1158/0008-5472.CAN-22-2233.
[18] Long Y, Ren Y, Wei Q, et al. NAT10-mediated RNA acetylation enhances HNRNPUL1 mRNA stability to contribute cervical cancer progression[J]. Int J Med Sci,2023,20:1079-1090. doi: 10.7150/ijms.83828.
[19] Chen X, Hao Y, Liu Y, et al. NAT10/ac4C/FOXP1 promotes malignant progression and facilitates immunosuppression by reprogramming glycolytic metabolism in cervical cancer[J]. Adv Sci (Weinh),2023,10:e2302705. doi: 10.1002/advs.202302705.
[20] Jin Z, Chai YD, Hu S, et al. Fatty acid metabolism and cancer[J]. Adv Exp Med Biol,2021,1280:231-241. doi: 10.1007/978-3-030-51652-9_16.
[21] Luo Y, Wang H, Liu B, et al. Fatty acid metabolism and cancer immunotherapy[J]. Curr Oncol Rep,2022,24:659-670. doi: 10.1007/s11912-022-01223-1.
[22] Dalhat MH, Mohammed MRS, Alkhatabi HA, et al. NAT10: an RNA cytidine transferase regulates fatty acid metabolism in cancer cells[J]. Clin Transl Med,2022,12:e1045. doi: 10.1002/ctm2.1045.
[23] Xiang Y, Zhou C, Zeng Y, et al. NAT10-mediated N4-acetylcytidine of RNA contributes to post-transcriptional regulation of mouse oocyte maturation in vitro[J]. Front Cell Dev Biol,2021,9:704341. doi: 10.3389/fcell.2021.704341.
[24] Lin J, Xiang Y, Huang J, et al. NAT10 maintains OGA mRNA stability through ac4C modification in regulating oocyte maturation[J]. Front Endocrinol,2022,13:907286. doi: 10.3389/fendo.2022.907286.
[25] Chen L, Wang WJ, Liu Q, et al. NAT10-mediated N4-acetylcytidine modification is required for meiosis entry and progression in male germ cells[J]. Nucleic Acids Res,2022,50:10896-10913. doi: 10.1093/nar/gkac594.