Progress of researches on inducing hepatic stellate cell ferroptosis for treatment of liver fibrosis

doi:10.16352/j.issn.1001-6325.2024.01.0108

Abstract

Abstract: Emerging evidence suggests that ferroptosis, an iron-dependent form of regulated cell death, plays a critical role in the genesis of liver fibrosis through inducing hepatic stellate cell (HSC) ferroptosis to inhibit liver fibrosis or inducing hepatic ferroptosis to potentiates liver fibrosis. Pharmacologically targeting at ferroptosis with its inducers can slow down the progression of liver fibrosis in vitro and in vivo model. This review suggests that pharmacological induction of HSC ferroptosis might be used as a potential novel targeted therapy for the treatment of liver fibrosis.

Key words: liver fibrosis, hepatic stellate cell, ferroptosis

CLC Number:

R575.5

SUN Lijie, HAO Dandan. Progress of researches on inducing hepatic stellate cell ferroptosis for treatment of liver fibrosis[J]. Basic & Clinical Medicine, 2024, 44(1): 108-113.

References 24

[1]	Kisseleva T, Brenner D. Molecular and cellular mechanisms of liver fibrosis and its regression[J]. Nat Rev Gastroenterol Hepatol, 2021,18:151-166.
[2]	Stockwell BR. Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications[J]. Cell, 2022,185:2401-2421.
[3]	Dhar D, Baglieri J, Kisseleva T, et al. Mechanisms of liver fibrosis and its role in liver cancer[J]. Exp Biol Med (Maywood), 2020,245:96-108.
[4]	Zhang Z, Yao Z, Wang L, et al. Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells[J]. Autophagy, 2018,14:2083-2103.
[5]	Zhang Z, Guo M, Shen M, et al. The BRD7-P53-SLC25A28 axis regulates ferroptosis in hepatic stellate cells[J]. Redox Biol, 2020,36:101619. doi:10.1016/j.redox.2020.101619.
[6]	Zhu Y, Zhang C, Huang M, et al. TRIM26 induces ferroptosis to inhibit hepatic stellate cell activation and mitigate liver fibrosis through mediating SLC7A11 ubiquitina-tion[J]. Front Cell Dev Biol, 2021,9:644901. doi:10.3389/fcell.2021.644901.
[7]	Zhang Z, Guo M, Li Y, et al. RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells[J]. Autophagy, 2020,16:1482-1505.
[8]	Wu A, Feng B, Yu J, et al. Fibroblast growth factor 21 attenuates iron overload-induced liver injury and fibrosis by inhibiting ferroptosis[J]. Redox Biol, 2021,46:102131. doi:10.1016/j.redox.2021.102131.
[9]	Song JX, An JR, Chen Q, et al. Liraglutide attenuates hepatic iron levels and ferroptosis in db/db mice[J]. Bioengineered, 2022,13:8334-8348.
[10]	Yi J, Wu S, Tan S, et al. Berberine alleviates liver fibrosis through inducing ferrous redox to activate ROS-mediated hepatic stellate cells ferroptosis[J]. Cell Death Discov, 2021,7:374. doi:10.1038/s41420-021-00768-7.
[11]	Que R, Cao M, Dai Y, et al. Decursin ameliorates carbon tetrachloride-induced liver fibrosis by facilitating ferro-ptosis of hepatic stellate cells[J]. Biochem Cell Biol, 2022,100:378-386.
[12]	Liu G, Wei C, Yuan S, et al. Wogonoside attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis through SOCS1/P53/SLC7A11 pathway[J]. Phytother Res, 2022,36:4230-4243.
[13]	Ho CH, Huang JH, Sun MS, et al. Wild bitter melon extract regulates LPS-induced hepatic stellate cell activa-tion, inflammation, endoplasmic reticulum stress, and ferroptosis[J]. Evid Based Complement Alternat Med, 2021,2021:6671129. doi:10.1155/2021/6671129.
[14]	Huang S, Wang Y, Xie S, et al. Isoliquiritigenin allevi-ates liver fibrosis through caveolin-1-mediated hepatic stellate cells ferroptosis in zebrafish and mice[J]. Phytomedicine, 2022,101:154117. doi:10.1016/j.phymed.2022. 154117.
[15]	Luo P, Liu D, Zhang Q, et al. Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1[J]. Acta Pharm Sin B, 2022,12:2300-2314.
[16]	Kuo CY, Chiu V, Hsieh PC, et al. Chrysophanol attenuates hepatitis B virus X protein-induced hepatic stellate cell fibrosis by regulating endoplasmic reticulum stress and ferroptosis[J]. J Pharmacol Sci, 2020,144:172-182.
[17]	Zhang Z, Wang X, Wang Z, et al. Dihydroartemisinin alleviates hepatic fibrosis through inducing ferroptosis in hepatic stellate cells[J]. Biofactors, 2021,47:801-818.
[18]	Wang N, Xu Q, Tan HY, et al. Berberine inhibition of fibrogenesis in a rat model of liver fibrosis and in hepatic stellate cells[J]. Evid Based Complement Alternat Med, 2016,2016:8762345. doi:10.1155/2016/8762345.
[19]	孔庆明, 戴方伟, 丁豪杰, 等. 青蒿琥酯抗小鼠血吸虫性肝纤维化的作用[J]. 中国药理学通报, 2019,35:854-858
[20]	彭龙希, 高思楠, 王媛, 等. 青蒿琥酯在大鼠体内外抗肝纤维化的作用[J]. 中国药理学通报, 2016,32:658-663
[21]	Kong Z, Liu R, Cheng Y. Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway[J]. Biomed Pharmacother, 2019,109:2043-2053.
[22]	Wang L, Zhang Z, Li M, et al. P53-dependent induction of ferroptosis is required for artemether to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation[J]. IUBMB Life, 2019,71:45-56.
[23]	Shen M, Li Y, Wang Y, et al. N6-methyladenosine modification regulates ferroptosis through autophagy signaling pathway in hepatic stellate cells[J]. Redox Biol, 2021,47:102151. doi:10.1016/j.redox.2021.102151.
[24]	Shen M, Guo M, Li Y, et al. m6A methylation is required for dihydroartemisinin to alleviate liver fibrosis by inducing ferroptosis in hepatic stellate cells[J]. Free Radic Biol Med, 2022,182:246-259.