Research progress of hypoxia inducible factor 1α in the mechanism of diabetic kidney disease

doi:10.16352/j.issn.1001-6325.2024.01.0114

Abstract

Abstract: Hypoxia-inducible factor-1α (HIF-1α) is a nuclear transcription factor. Under high glucose and hypoxia conditions, the expression of HIF-1α is elevated, result in the increased expression of its downstream target genes VEGF, HO-1 and BNIP3, which affect angiogenesis, extra cellular matrix deposition, iron metabolism, and mitophagy, participating in the occurrence and development of diabetic kidney disease (DKD). In addition, HIF-1α promotes inflammation and renal fibrosis by affecting the production of cytokines in DKD.

Key words: hypoxia inducible factor 1α, diabetic kidney disease, pathogenesis

CLC Number:

R587.1

ZHANG Yahui, BAI Qiong. Research progress of hypoxia inducible factor 1α in the mechanism of diabetic kidney disease[J]. Basic & Clinical Medicine, 2024, 44(1): 114-118.

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