Progress on poly(C)-binding protein 1 in ferroptosis

doi:10.16352/j.issn.1001-6325.2025.11.1501

Abstract

Abstract: Poly(C)-binding protein 1 (PCBP1) is a multifunctional RNA-binding protein involved in a series of processes such as gene transcription, selective modification, translation and regulation of iron metabolism . This paper explores the pathway through which PCBP1 inhibits ferroptosis during the research on PCBP1-related diseases, such as bladder cancer and head and neck cancer. PCBP1 can reduce the intracellular ferrous iron content to inhibit ferroptosis through the mechanisms like inhibiting ferritinophagy,promoting the transfer of iron ions to ferritin or iron-dependent enzymes, stabilizing the labile iron pool within cells and facilitating the formation of[2Fe-2S] clusters. PCBP1 can also reduce the generation of lipid peroxides and enhance the resistance to oxidative stress thus to reduce the level of intracellular reactive oxygen thereby inhibiting ferroptosis.

Key words: poly(C)-binding protein 1 (PCBP1), ferroptosis, ferritin, lipid peroxidation

CLC Number:

LIU Tianna, LI Yang, DENG Yudi, WU Fuju. Progress on poly(C)-binding protein 1 in ferroptosis[J]. Basic & Clinical Medicine, 2025, 45(11): 1501-1505.

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