Basic & Clinical Medicine ›› 2023, Vol. 43 ›› Issue (10): 1594-1598.doi: 10.16352/j.issn.1001-6325.2023.10.1594

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Research progress of sodium-glucose cotransporter 2 inhibitor in non-alcoholic fatty liver disease

HUANG Lichenlu1, ZHANG Jiarui1, ZHENG Yongqin2, HE Jundong2*   

  1. 1. Medical School,Kunming University of Science and Technology,Kunming 650500;
    2. Department of Endocrinology and Metabolism, the Affiliated Hospital of Kunming University of Science and Technology, the First People's Hospital of Yunnan Province,Kunming 650500, China
  • Received:2022-12-12 Revised:2023-04-10 Online:2023-10-05 Published:2023-10-05
  • Contact: *hejd1227@163.com

Abstract: Sodium-glucose cotransporter 2 inhibitor (SGLT-2i) is a new type of anti-diabetes drug. Clinical studies have shown that SGLT-2i plays a beneficial role in the treatment of patients with non-alcoholic fatty liver disease (NAFLD). SGLT-2i can reduce hepatic endoplasmic reticulum stress, regulate inflammatory reaction, improve liver fibrosis and increase hepatocyte autophagy to alleviate symptoms of NAFLD patients.

Key words: non-alcoholic fatty liver disease, sodium-glucose cotransporter 2 inhibitor

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