JAK-STAT signaling pathway and diabetic complications

doi:10.16352/j.issn.1001-6325.2023.10.1590

Abstract

Abstract: Diabetes mellitus and the complications seriously affect the health and life quality of patients. In recent years, more and more studies have shown that JAK-STAT signaling pathway plays an important role in the development and treatment of diabetic complications. This review focuses on the research progress of JAK-STAT pathway and diabetes, peripheral neuropathy, diabetic nephropathy, diabetic retinopathy and diabetic cardiomyopathy.

Key words: JAK/STAT signaling pathway, diabetes mellitus, diabetic complications

CLC Number:

R285.5

YU Ziman, ZHAO Bingjia, YANG Dan. JAK-STAT signaling pathway and diabetic complications[J]. Basic & Clinical Medicine, 2023, 43(10): 1590-1593.

References 21

[1]	Cole JB, Florez JC. Genetics of diabetes mellitus and diabetes complications[J]. Nat Rev Nephrol, 2020, 16: 377-390.
[2]	Xin P, Xu X, Deng C, et al. The role of Jak/Stat signaling pathway and its inhibitors in diseases[J]. Int Immunopharmacol, 2020, 80: 106210.doi:10.1016/j.intimp.2020.106210.
[3]	Gurzov EN, Stanley WJ, Pappas EG, et al. The Jak/Stat pathway in obesity and diabetes[J]. FEBS J, 2016, 283: 3002-3015.
[4]	O'Shea JJ, Schwartz DM, Villarino AV, et al. The Jak-Stat pathway: impact on human disease and therapeutic intervention[J]. Annu Rev Med, 2015, 66: 311-328.
[5]	Callaghan BC, Cheng HT, Stables CL, et al. Diabetic neuropathy: clinical manifestations and current treatments[J]. Lancet Neurol, 2012, 11: 521-534.
[6]	Du W, Wang N, Li F, et al. Stat3 phosphorylation mediates high glucose-impaired cell autophagy in an Hdac1-dependent and -independent manner in Schwann cells of diabetic peripheral neuropathy[J]. FASEB J, 2019, 33: 8008-8021.
[7]	Ren J, Zhu B, Gu G, et al. Schwann cell-derived exosomes containing Mfg-E8 modify macrophage/microglial polarization for attenuating inflammation via the Socs3/Stat3 pathway after spinal cord injury[J]. Cell Death Dis, 2023, 14: 70.doi:10.1038/s41419-023-05607-4.
[8]	Chowdhury SR, Saleh A, Akude E, et al. Ciliary neurotrophic factor reverses aberrant mitochondrial bioenergetics through the Jak/Stat pathway in cultured sensory neurons derived from streptozotocin-induced diabetic rodents[J]. Cell Mol Neurobiol, 2014, 34: 643-649.
[9]	Saleh A, Chowdhury SK, Smith DR, et al. Diabetes impairs an interleukin-1β-dependent pathway that enhances neurite outgrowth through Jak/Stat3 modulation of mitochondrial bioenergetics in adult sensory neurons[J]. Mol Brain, 2013, 6: 45.doi:10.1186/1756-6606-6-45.
[10]	Yao D, Li M, Shen D, et al. Expression changes and bioinformatic analysis of wallerian degeneration after sciatic nerve injury in rat[J]. Neurosci Bull, 2013, 29: 321-332.
[11]	Calle P, Hotter G. Macrophage phenotype and fibrosis in diabetic nephropathy[J]. Int J Mol Sci, 2020, 21.doi:10.3390/ijms21082806.
[12]	Zitman-gal T, Einbinder Y, Ohana M, et al. Effect of liraglutide on the Janus kinase/signal transducer and transcription activator (Jak/Stat) pathway in diabetic kidney disease in db/db mice and in cultured endothelial cells[J]. J Diabetes, 2019, 11: 656-664.
[13]	Zhang Y, Jin D, Kang X, et al. Signaling pathways involved in diabetic renal fibrosis[J]. Front Cell Dev Biol, 2021, 9: 696542.doi:10.3389/fcell.2021.696542.
[14]	Berthier CC, Zhang H, Schin M, et al. Enhanced expression of Janus kinase-signal transducer and activator of transcription pathway members in human diabetic nephropathy[J]. Diabetes, 2009, 58: 469-477.
[15]	Tuttle KR, Brosius FC, Adler SG, et al. Jak1/Jak2 inhibition by baricitinib in diabetic kidney disease: results from a phase 2 randomized controlled clinical trial[J]. Nephrol Dial Transplant, 2018, 33: 1950-1959.
[16]	Tam TE, Wong TY. Diabetic retinopathy: looking forward to 2030[J]. Front Endocrinol (Lausanne), 2022, 13: 1077669.doi:10.3389/fendo.2022.1077669.
[17]	Meng F, Guo B, Ma YQ, et al. Puerarin: a review of its mechanisms of action and clinical studies in ophthalmology [J]. Phytomedicine, 2022, 107: 154465.doi:10.1016/j.phymed.2022.154465.
[18]	Cho CH, Roh KH, Lim NY, et al. Role of the Jak/Stat pathway in a streptozotocin-induced diabetic retinopathy mouse model[J]. Graefes Arch Clin Exp Ophthalmol, 2022, 260: 3553-3563.
[19]	Dillmann WH. Diabetic cardiomyopathy[J]. Circ Res, 2019, 124: 1160-1162.
[20]	Khadrawy SM, EL Sayed RA. Umbelliferone attenuates diabetic cardiomyopathy by suppression of Jak/Stat signaling pathway through amelioration of oxidative stress and inflammation in rats[J]. J Biochem Mol Toxicol, 2023, 37: e23296.doi:10.1002/jbt.23296.
[21]	EL-Sayed N, Mostafa YM, Abogresha NM, et al. Dapagliflozin attenuates diabetic cardiomyopathy through erythro-poietin up-regulation of Akt/Jak/Mapk pathways in streptozotocin-induced diabetic rats[J]. Chem Biol Interact, 2021, 347:109617.doi:10.1016/j.cbi.2021.109617.