Abstract: Objectives To investigate the clinical character of the large-cell neuroendocrine carcinomas(LCNECs), and analyze the clinical factors or treatment methods related to prognosis. Methods Collect the 37 patients data from 1994.4.30 to 2014.4.30 in our hospital(PUMCH), and analyzed retrospectively. Results LCNEC occurs in older men with heavy smoking history, clinical manifestations, imaging and laboratory examination lack of specificity. Immunohistochemically neuroendocrine specific markers Syn, CgA and CD56 positive expression rates were: 75.7%、59.5% and 67.6%, respectively. 27 patients receive surgical treatment, 10 patients received adjuvant chemotherapy, 8 underwent palliative radiotherapy. Univariate analysis indicated that tumor-node-metastasis (TNM) stage(P<0.01) is prognostic factor. Surgery is a prognostic factor for patients with limited term（p<0.05）. for patients with stage III radiotherapy is a prognostic factor（p<0.05）. Conclusion LCNEC lack specific clinical symptoms, diagnosis depends on pathology, the treatment effect is poor. TNM stage is an important prognostic factor. Surgery for the patients with limited stage affect the prognosis, radiotherapy for patients with stage III may improve the survival rate.

Key words: lung neoplasms, neuroendocrine carcinoma, large cell carcinoma, radiotherapy, prognosis