Abstract: Bacteriophage lysin has high stability, wide bactericidal, strong antibacterial properties and safty. It is able to lysis bacteria specifically and is not susceptible to bacterial resistance. In the presence of phage, phage infecting bacteria and coding for endolysin then it lysis the bacteria from interior, In the absence of the phage, holin assists the endolysin lysis the bacteria from external. In addition, the research progress on the treatment of gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus, Streptococcus pyogenes, and gram-negative bacteria, such as Acinetobacter baumannii and Pseudomonas aeruginosa, was also discussed in this paper.

Key words: Phage, lysin, therapy, antibacterial mechanism