Abstract: Tumor stem cells (TSCs), because of its close relations to occurrence, development, metastasis, recurrence and drug resistance of tumor, is considered by research commnity as root cause of the tumor cells. In other words, The key way to cure tumor may be to eradicate TSCs. The traditional surgery, chemotherapy and radiotherapy not only have rare effect in killing TSCs, but also result in recurrence and metastasis easily. However, TSCs can definitely killed by the immunotherapy targeting TSCs, for instance, targeting the surface antigens of TSCs’, T cells targeting the TSCs, differentiation therapy and so on.

Key words: tumor, tumor stem cells, immunotherapy