Abstract: Long non-coding RNAs(lncRNAs) are a class of non-coding RNAs longer than 200 nucleotides and are closely related to the occurrence and development of gastric cancer. The abnormal expression of lncRNAs affects the biological processes of gastric cancer cells. For instance, lncRNA HOTAIR, GHET1, DANCR, HULC and MEG3 can regulate the occurrence, development, invasion and metastasis of gastric cancer via multiple mechanisms such as epigenetic, transcriptional and post-transcriptional levels. Therefore, lncRNAs are expected to become new biomarkers for diagnosis and treatment of gastric cancer and have potential guiding significance for therapy and prognosis.

Key words: long non-coding RNAs, gastric cancer, biomarkers, epigenetic regulation