Abstract: Thrombin activatable fibrinolysis inhibitor (TAFI) is a kind of plasma enzymes that can be activated by thrombin. TAFI regulates blood coagulation and fibrinolysis and has a strong fibrinolytic and anti-inflammatory activity. Its inhibitor is expected to avoid the risk of bleeding when thrombolytic recanalization. Also, studies found that TAFI played an important role in the development of cerebral thrombosis; atherosclerosis and so on.

Key words: thrombin activation of fibrinolysis inhibitor (TAFI), cerebral thrombosis, cardiovascular disease