Abstract: Autophagy is a so important metabolism mechanism that involved in various stress responses of cells such as inflammation. A close molecular connection between autophagy and inflammation. One side, some inflammatory mediators can regulate autophagy and its translation; The other side, autophagy is able to suppress the excessive inflammation in various manners. Therefore, deficient autophagy may associate with inflammatory diseases such as Crohn’s Disease (CD).

Key words: Autophagy, inflammation, Crohn’s Disease