Role of anti-aging Klotho gene in inflammatory responses and fibrosis

doi:10.16352/j.issn.1001-6325.2025.10.1382

Abstract

Abstract: The anti-aging Klotho gene can not only delay the aging process but also regulate fibrosis and inflammatory responses by influencing inflammatory cells such as monocytes-macrophages, T cells, and B cells. It can regulate the processes related to fibrosis and inflammatory responses through inflammatory pathways such as fibroblast growth factor (FGF), transforming growth factor-β(TGF-β), Toll-like receptor(TLR), nuclear factor-κB(NF-κB), and the renin-angiotensin system (RAS). Thus, elucidating the molecular mechanisms by which Klotho regulates inflammatory responses and fibrosis, and developing targeted intervention strategies to upregulate Klotho levels based on these mechanisms, may provide new theoretical basis and therapeutic targets for the prevention and treatment of related diseases.

Key words: Klotho, anti-aging, inflammation, tissue fibrosis

CLC Number:

R363.1

YE Min, GUO Xiuying, WANG Danxin, HE Guangliang. Role of anti-aging Klotho gene in inflammatory responses and fibrosis[J]. Basic & Clinical Medicine, 2025, 45(10): 1382-1386.

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