Progress of PANoptosis in age-related diseases

doi:10.16352/j.issn.1001-6325.2025.11.1506

Abstract

Abstract: PANoptosis is a novel mode of cell death that intelligently initiates signaling pathways by forming PANoptosome. It can promote the development of retinopathy and nephropathy by regulating the inflammatory response and cell death triggered by hyperglycemia. It activates inflammasome release and plays a role in Alzheimer's disease (AD) and osteoarthritis. Similarly,PANoptosis can promote cochlear aging by damaging mitochondria, changing immune response and inducing inflammatory response, aiming to provide new therapeutic ideas for the disease.

Key words: cell death, PANoptosis, age-related

CLC Number:

ZHANG Yue, WANG Junying. Progress of PANoptosis in age-related diseases[J]. Basic & Clinical Medicine, 2025, 45(11): 1506-1510.

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