肥胖促进哮喘发作的研究进展

doi:10.16352/j.issn.1001-6325.2025.08.1103

基础医学与临床 ›› 2025, Vol. 45 ›› Issue (8): 1103-1107.doi: 10.16352/j.issn.1001-6325.2025.08.1103

肥胖促进哮喘发作的研究进展

向韵瑄, 常晓悦^*

内蒙古医科大学包头临床医学院呼吸与危重症医学科, 内蒙古包头 014040

收稿日期:2024-12-18 修回日期:2025-04-25 出版日期:2025-08-05 发布日期:2025-07-11
通讯作者: ^*btchangxiaoyue@163.com

Advances in obesity promoting asthma exacerbations

XIANG Yunxuan, CHANG Xiaoyue^*

Department of Pulmonary Critical Care Medicine, Baotou Clinical Medical College, Inner Mongolia Medical University, Baotou 014040, China

Received:2024-12-18 Revised:2025-04-25 Online:2025-08-05 Published:2025-07-11
Contact: ^*btchangxiaoyue@163.com

摘要/Abstract

摘要： 肥胖可以促进哮喘发作,其作用机制复杂,涉及机械力学、炎性反应、基因遗传、微生物组成及代谢综合征等方面。肥胖可使肺组织和胸壁的顺应性降低,增加气道阻力,导致气道狭窄,加重哮喘症状。肥胖可增加炎性因子的释放,加重哮喘的气道炎性反应。肥胖可通过基因遗传影响肥胖表型而增加患哮喘的风险。肥胖可改变微生物群的组成而影响哮喘的发展。肥胖还可通过引起一系列代谢综合征使哮喘恶化。总之,肥胖促进哮喘的相关机制涉及多系统交互作用。在肥胖相关性哮喘的治疗上,靶向代谢药物和生物制剂也展现出巨大潜力。

关键词: 哮喘, 肥胖, 机制, 治疗

Abstract: Obesity can promote asthma exacerbations by a complex mechanism of action involving multi-system interactions such as mechanomechanics, inflammatory response, genetic inheritance, microbial composition and metabolic syndrome. Obesity reduces the compliance of lung tissue and chest wall, increases airway resistance, leads to airway narrowing, and aggravates asthma symptoms. Obesity can increase the release of inflammatory factors and aggravate the airway inflammatory response in asthma. Obesity can increase the risk of asthma by genetically influencing the obesity phenotype. Obesity can affect the development of asthma by altering the composition of the microbiota. Obesity can also worsen asthma by causing a series of metabolic syndrome. In conclusion,the mechanisms associated with obesity-promoted asthma involve multi-system interactions. Targeted metabolic drugs and biologics also show great potential in the treatment of obesity-associated asthma.

Key words: asthma, obesity, mechanisms, treatment

中图分类号:

R562.2

向韵瑄, 常晓悦. 肥胖促进哮喘发作的研究进展[J]. 基础医学与临床, 2025, 45(8): 1103-1107.

XIANG Yunxuan, CHANG Xiaoyue. Advances in obesity promoting asthma exacerbations[J]. Basic & Clinical Medicine, 2025, 45(8): 1103-1107.

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肥胖促进哮喘发作的研究进展

Advances in obesity promoting asthma exacerbations

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