原发性心包间皮瘤的临床特征与预后

doi:10.16352/j.issn.1001-6325.2025.02.0222

基础医学与临床 ›› 2025, Vol. 45 ›› Issue (2): 222-228.doi: 10.16352/j.issn.1001-6325.2025.02.0222

原发性心包间皮瘤的临床特征与预后

聂牧文, 孙昭, 李宁宁, 赵林^*, 白春梅^*

中国医学科学院北京协和医学院北京协和医院肿瘤内科,北京 100730

收稿日期:2024-04-07 修回日期:2024-09-27 出版日期:2025-02-05 发布日期:2025-01-17
通讯作者: ^*wz20010727@aliyun.com;baichunmei@pumch.cn
基金资助:
中央高水平医院临床科研专项(2022PUMCH-B-051)

Clinical characteristics and prognosis of primary pericardial mesothelioma

NIE Muwen, SUN Zhao, LI Ningning, ZHAO Lin^*, BAI Chunmei^*

Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Received:2024-04-07 Revised:2024-09-27 Online:2025-02-05 Published:2025-01-17
Contact: ^*wz20010727@aliyun.com;baichunmei@pumch.cn

摘要/Abstract

摘要： 目的探讨原发性心包间皮瘤(PPM)的临床、病理、影像特征、治疗及预后。方法回顾性收集了2014年到2024年在北京协和医院确诊的11例PPM患者的临床、病理及影像学资料,用Log-Rank检验估算患者的Kaplan-Meier曲线,明确患者的预后因素。结果 11例患者的中位年龄48岁,1例为高分化乳头状间皮瘤,10例为恶性间皮瘤。所有患者CA125均升高。PET/CT结果均提示心包代谢增高。男性患者与ECOG评分＞2分的患者预后更差(分别为P=0.018,P=0.01)。对比未治疗组(4例),免疫治疗(3例)和化疗(3例)均能延长患者生存(分别为P=0.025,P=0.025),且免疫治疗相比于化疗的获益更大(P=0.049 9)。结论本研究是中国目前最大的单中心心包间皮瘤队列。CA125及PET/CT有助于PPM的诊断,免疫治疗是PPM治疗未来探索的方向。

关键词: 原发性心包间皮瘤, 诊断, 免疫治疗, 预后

Abstract: Objective To explore the clinical, pathological, imaging characteristics, treatment, and prognosis of primary pericardial mesothelioma (PPM). Methods The clinical,pathological and imaging data of 11 PPM patients diagnosed in Peking Union Medical College Hospital from 2014 to 2024 were retrospectively collected,the Kaplan-Meier curve was calculated by Log-Rank test to determine the prognostic factors of the patients. Results The median age of the 11 patients was 48 years, including one well-differentiated papillary mesothelioma, and ten malignant mesothelioma. CA125 was elevated in all patients. PET/CT all indicated increased pericardial metabolism. Male patients and patients with ECOG score ＞2 points had worse prognosis (P=0.018, P=0.01, respectively). Compared with the untreated group(4 cases), both immunotherapy(3 cases) and chemotherapy(3 cases) can prolong patient survival (P=0.025, P=0.025, respectively), and the benefit of immunotherapy was greater than chemotherapy (P=0.049 9). Conclusions This study is the largest single center pericardial mesothelioma cohort in China. CA125 and PET/CT contributes to the diagnosis of PPM, and immunotherapy might be the future direction of PPM treatment.

Key words: primary pericardial mesothelioma, diagnosis, immunotherapy, prognosis

中图分类号:

R732.1

聂牧文, 孙昭, 李宁宁, 赵林, 白春梅. 原发性心包间皮瘤的临床特征与预后[J]. 基础医学与临床, 2025, 45(2): 222-228.

NIE Muwen, SUN Zhao, LI Ningning, ZHAO Lin, BAI Chunmei. Clinical characteristics and prognosis of primary pericardial mesothelioma[J]. Basic & Clinical Medicine, 2025, 45(2): 222-228.

参考文献 11

[1]	Huang J, Chan SC, Pang WS, et al. Global incidence, risk factors, and temporal trends of mesothelioma: apopulation-based study[J]. J Thorac Oncol, 2023, 18: 792-802.
[2]	Offin M, De Silva DL, Sauter JL, et al. Multimodality therapy in patients with primary pericardial mesothelioma[J]. J Thorac Oncol, 2022, 17: 1428-1432.
[3]	Wang Q, Xu C, Wang W, et al. Chinese expert consensus on the diagnosis and treatment of malignant pleural mesothelioma[J]. Thorac Cancer, 2023, 14: 2715-2731.
[4]	McGehee E, Gerber DE, Reisch J, et al. Treatment and outcomes of primary pericardial mesothelioma: a contemporary review of 103 published cases[J]. Clin Lung Cancer, 2019, 20: e152-e157.
[5]	Marinaccio A, Consonni D, Mensi C, et al. Association between asbestos exposure and pericardial and tunica vaginalis testis malignant mesothelioma: a case-control study and epidemiological remarks[J]. Scandi J Work, Environ Health, 2020, 46: 609-617.
[6]	Baratti D, Kusamura S, Martinetti A, et al. Circulating CA125 in patients with peritoneal mesothelioma treated with cytoreductive surgery and intraperitoneal hyperthermic perfusion[J]. Ann Surg Oncol, 2007, 14: 500-508.
[7]	Kong L, Li ZW, Wang JR, et al. Echocardiographic characteristics of primary malignant pericardial mesothelioma and outcomes analysis: a retrospective study[J]. Cardio Ultrasound, 2018, 16:7.doi: 10.1186/s12947-018-0125-z.
[8]	Husain AN, Colby T, Ordonez N, et al. Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the International Mesothelioma Interest Group[J]. Arch Pathol Lab Med, 2013, 137: 647-667.
[9]	Wang X, Ren W, Xiao Y, et al. A giant, well-differentiated papillary mesothelioma of the left atrioventricular groove: case report and brief review of the literature[J]. J Clin Ultrasound, 2019, 47: 564-567.
[10]	Forde PM, Anagnostou V, Sun ZX, et al. Durvalumab with platinum-pemetrexed for unresectable pleural mesothelioma: survival, genomic and immunologic analyses from the phase 2 PrE0505 trial[J]. Nat Med, 2021, 27: 1910-1920.
[11]	Baas P, Scherpereel A, Nowak A-K, et al. First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): a multicentre, randomised, open-label, phase 3 trial[J]. Lancet, 2021, 397: 375-386.

编辑推荐 0

Metrics

阅读次数

全文

HTML			PDF

最新录用	在线预览	正式出版	最新录用	在线预览	正式出版
0	0	0	0	0	11

	来源	本网站

	次数	11
	比例	100%

摘要

最新录用	在线预览	正式出版

0	0	44

	来源	本网站

	次数	44
	比例	100%

[1]	贾会文, 刘赟, 徐赟, 杨启, 杨科. 原发性肝癌血清miR-409-3p和miR-325-3p与介入治疗疗效相关[J]. 基础医学与临床, 2025, 45(3): 341-345.
[2]	吴慧珊, 廖颖萍, 李萌. 衰弱患者氨基酸代谢特征的研究进展[J]. 基础医学与临床, 2025, 45(2): 253-257.
[3]	彭定越, 王玮婧, 张为, 杨乙, 包卓华, 吕渊, 李淑娟. 急性胼胝体梗死患者的临床特征和预后分析[J]. 基础医学与临床, 2025, 45(2): 234-238.
[4]	李星辰, 童瑾. 鉴别肺孢子菌感染与定植的研究进展[J]. 基础医学与临床, 2025, 45(1): 116-120.
[5]	张丽娜, 贾梦涛, 孙泽云, 张建军. miR-483-3p在妊娠期糖尿病患者血清中的表达及临床意义[J]. 基础医学与临床, 2025, 45(1): 91-97.
[6]	黄航栋, 厉丹瑜, 朱晓锋. 血清PKM2、Gal-3、CitH3水平升高可预测机械通气并发肺部感染[J]. 基础医学与临床, 2025, 45(1): 86-90.
[7]	李顺乐, 李蓉, 田亚亚, 冉小丽, 赵延培, 徐蒙. 血清KLF5和actinin-4水平与肝细胞肝癌肝动脉化疗栓塞术治疗预后的关系[J]. 基础医学与临床, 2024, 44(9): 1284-1289.
[8]	付志刚, 覃佳, 谭江山. 门脉高压性肺动脉高压:诊治进展与挑战[J]. 基础医学与临床, 2024, 44(8): 1068-1073.
[9]	侯楠, 刘源, 高俊, 王晶, 袁萌. 全血NPM1、MCP-1和肠道菌群与胃癌进展及预后相关[J]. 基础医学与临床, 2024, 44(8): 1137-1142.
[10]	胡潮兴, 梁秋冬, 吴大鹏. 血清SAA4和SOCS1对脊柱结核与化脓性脊柱炎的早期鉴别价值[J]. 基础医学与临床, 2024, 44(7): 997-1001.
[11]	张睿, 谭妍, 马东来, 王蓉蓉, 张学. KIT杂合大片段缺失导致斑驳病一家系的临床表型[J]. 基础医学与临床, 2024, 44(7): 954-958.
[12]	操辰新, 唐辉, 耿瑞璇, 郭伏平, 白春梅, 王颖轶, 李太生. 循环CD4⁺CD45RA⁺CD62L⁺ T细胞与接受EGFR-TKI治疗的转移性非小细胞肺癌预后相关[J]. 基础医学与临床, 2024, 44(5): 658-664.
[13]	王宇, 童安莉, 周玥, 张文倩, 崔云英, 景红丽, 李玉秀. ^99mTc-HYNIC-TOC显像和¹³¹I-MIBG显像在嗜铬细胞瘤和副神经节瘤中的诊断价值[J]. 基础医学与临床, 2024, 44(3): 374-378.
[14]	赵永忠, 薛懿, 李立群, 侯孟森, 杨晓军. 胆囊癌的早期影像学及循环标志物特征[J]. 基础医学与临床, 2024, 44(2): 265-269.
[15]	丁飞, 王洒, 黄常新. 非小细胞肺癌患者血清CA211水平和NK细胞数与预后相关[J]. 基础医学与临床, 2024, 44(2): 180-184.

原发性心包间皮瘤的临床特征与预后

Clinical characteristics and prognosis of primary pericardial mesothelioma

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献 11

相关文章 15

编辑推荐 0

Metrics

本文评价