长链非编码RNA与疾病

doi:10.16352/j.issn.1001-6325.2024.10.1465

基础医学与临床 ›› 2024, Vol. 44 ›› Issue (10): 1465-1469.doi: 10.16352/j.issn.1001-6325.2024.10.1465

长链非编码RNA与疾病

李文超, 李祥生, 李富光, 张志永, 惠磊, 周文科^*

新乡医学院第一附属医院神经外科,河南新乡 453000

收稿日期:2023-12-11 修回日期:2024-04-02 出版日期:2024-10-05 发布日期:2024-09-27
通讯作者: ^* Zhouwenke1999@163.com
基金资助:
新乡医学院博士科研基金(12353)

Long non-coding RNA and diseases

LI Wenchao, LI Xiangsheng, LI Fuguang, ZHANG Zhiyong, HUI Lei, ZHOU Wenke^*

Department of Neurosurgery, the First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453000, China

Received:2023-12-11 Revised:2024-04-02 Online:2024-10-05 Published:2024-09-27
Contact: ^* Zhouwenke1999@163.com

摘要/Abstract

摘要： 长链非编码RNA(lncRNA)是一类长度大于200 nt的内源性非编码RNA。因其缺乏开放阅读框(ORF),故不具备直接编码蛋白质的能力,但其在基因调控中却起关键作用。LncRNAs广泛参与表观遗传、转录、翻译及修饰、降解从而影响机体的生命活动过程,其表达失调与疾病的发生发展密切相关。因此解析lncRNAs的自身特性并揭示其内在作用,不仅可以加深对人体生理和病理过程的认识,也可以为疾病的诊断、预防和治疗提供新的思路和潜在解决途径。

关键词: 非编码RNA, 肿瘤, 神经系统, 疾病, 表观遗传学

Abstract: Long non-coding RNA (lncRNA) is a class of endogenous non-coding RNA with a length of more than 200 nt. Due to lack of open reading frame (ORF), they lack the ability to directly encode proteins, but they play a crucial role in gene regulation. They are widely involved in epigenetics, transcription, translation, modification and degradation, thereby affecting the life activities of the body, and their expression imbalance is closely related to the occurrence and development of diseases. Therefore, analyzing the inherent characteristics of lncRNA and revealing its intrinsic role can not only deepen our understanding of human physiological and pathological processes, but also provide new ideas and potential solutions for the diagnosis, prevention and treatment of diseases. So as to provide references for the related research of lncRNAs.

Key words: non-coding RNA, tumors, nervous system, disease, epigenetics

中图分类号:

R456

李文超, 李祥生, 李富光, 张志永, 惠磊, 周文科. 长链非编码RNA与疾病[J]. 基础医学与临床, 2024, 44(10): 1465-1469.

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长链非编码RNA与疾病

Long non-coding RNA and diseases

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