Ghrelin在胃癌中的作用

doi:10.16352/j.issn.1001-6325.2024.10.1460

基础医学与临床 ›› 2024, Vol. 44 ›› Issue (10): 1460-1464.doi: 10.16352/j.issn.1001-6325.2024.10.1460

Ghrelin在胃癌中的作用

李炜康, 李东宝, 任嘉裕, 孙小童, 段开鹏, 周进^*

江苏省苏州大学附属第一医院普通外科,江苏苏州 215006

收稿日期:2023-11-06 修回日期:2024-04-01 出版日期:2024-10-05 发布日期:2024-09-27
通讯作者: ^* zhoujinsuda@suda.edu.cn
基金资助:
国家自然科学基金(81871952,82372887);江苏省自然科学基金资助(BK20221242);江苏省社会发展(BE2020657);苏州市第五批姑苏卫生人才培养(GSWS2019008);苏州市临床重点病种诊疗技术专项(LCZX202202)

Role of Ghrelin in gastric cancer

LI Weikang, LI Dongbao, REN Jiayu, SUN Xiaotong, DUAN Kaipeng, ZHOU Jin^*

Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou 215006, China

Received:2023-11-06 Revised:2024-04-01 Online:2024-10-05 Published:2024-09-27
Contact: ^* zhoujinsuda@suda.edu.cn

摘要/Abstract

摘要： Ghrelin是一种新发现的胃肠肽,参与调节机体生长发育与能量平衡,并在恶性肿瘤的发生进展中发挥关键作用,比如参与细胞增殖、迁移、侵袭、凋亡、炎性反应和免疫细胞浸润等。Ghrelin 通过激活NF-κB/p65、AMPK等信号通路影响胃癌进展。Ghrelin不仅可以辅助胃癌早期筛查,还可能成为新的预测胃癌患者预后生存的标志物。Ghrelin及其类似物有治疗胃癌相关综合症如恶病质或肌肉减少症的临床应用前景。

关键词: Ghrelin, 胃癌, 信号通路, 肌肉减少症, 模拟治疗

Abstract: Ghrelin is a newly discovered gastrointestinal peptide that is involved in regulating the body's growth, development and energy balance, and plays a key role in the occurrence and progression of malignant tumors, such as cell proliferation, migration, invasion, apoptosis, inflammatory response and vascular disease. Generate immune cell infiltration and so on. Ghrelin affects the progression of gastric cancer by activating NF-κB/p65 and AMPK and other signaling pathways. Ghrelin not only assist in early screening of gastric cancer, but also function a new marker for predicting the prognosis and survival of gastric cancer patients. Ghrelin and its analogs have clinical application value in the treatment of gastric cancer-related syndromes such as cachexia or sarcopenia.

Key words: Ghrelin, gastric cancer, signaling pathway, sarcopenia, simulation therapy

中图分类号:

R735.2

李炜康, 李东宝, 任嘉裕, 孙小童, 段开鹏, 周进. Ghrelin在胃癌中的作用[J]. 基础医学与临床, 2024, 44(10): 1460-1464.

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Ghrelin在胃癌中的作用

Role of Ghrelin in gastric cancer

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