防治子宫内膜损伤的策略

doi:10.16352/j.issn.1001-6325.2024.09.1308

基础医学与临床 ›› 2024, Vol. 44 ›› Issue (9): 1308-1313.doi: 10.16352/j.issn.1001-6325.2024.09.1308

防治子宫内膜损伤的策略

李佳铭¹, 杨超^2*, 麻莉^2*

1.锦州医科大学火箭军特色医学中心研究生培养基地,北京 100088;
2.中国人民解放军火箭军特色医学中心,北京 100088

收稿日期:2023-11-15 修回日期:2024-03-29 出版日期:2024-09-05 发布日期:2024-08-30
通讯作者: ^*yangchao0120@126.com; lmhmm52@yeah.net
基金资助:
军队后勤科研项目(HQKY22015);火箭军特色医学中心科研创新项目(4173176)

Strategies for the prevention and treatment of endometrial injury

LI Jiaming¹, YANG Chao^2*, MA Li^2*

1. Training Base for Postgraduate Students, PLA Rocket Force Characteristic Medical Center of Jinzhou Medical University, Beijing 100088;
2. Chinese PLA Rocket Force Characteristic Medical Center, Beijing 100088, China

Received:2023-11-15 Revised:2024-03-29 Online:2024-09-05 Published:2024-08-30
Contact: ^*yangchao0120@126.com; lmhmm52@yeah.net

摘要/Abstract

摘要： 子宫内膜损伤是指由宫腔内有创诊疗操作、炎性损伤、物理辐射、化学药物损伤及分娩相关憩室等多种因素导致的内膜基底层损伤。应用透明质酸、脱细胞基质、羊膜、富含血小板血浆、间充质干细胞(尤其是基于支架的治疗递送)可减少损伤后瘢痕形成,促进子宫内膜生长修复,为修复受损的子宫内膜,提高其容受性,改善生育结局提供新的治疗思路。

关键词: 子宫内膜损伤, 修复, 再生, 宫腔粘连

Abstract: Endometrial injury is the main fact leading to the damage of endometrial basal layer. It is usually caused by traumatic treatment, inflammatory injury, radiation, chemical drug-related injury, and delivery-related diverticulum. The use of hyaluronic acid, decellularized matrix, amniotic membrane, platelet-rich plasma, mesenchymal stem cells (especially scaffold-based therapeutic delivery) has been proved to reduce post-injury scar formation and promote endometrial growth and repair, which provides a new therapeutic strategy for repairing the damaged endometrium with improved tolerability and fertility outcomes.

Key words: endometrial injury, repairment, regeneration, intrauterine adhesion

中图分类号:

711.74

李佳铭, 杨超, 麻莉. 防治子宫内膜损伤的策略[J]. 基础医学与临床, 2024, 44(9): 1308-1313.

LI Jiaming, YANG Chao, MA Li. Strategies for the prevention and treatment of endometrial injury[J]. Basic & Clinical Medicine, 2024, 44(9): 1308-1313.

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防治子宫内膜损伤的策略

Strategies for the prevention and treatment of endometrial injury

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