脐带间充质干细胞修复皮肤创伤的研究进展

doi:10.16352/j.issn.1001-6325.2022.11.1771

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (11): 1771-1775.doi: 10.16352/j.issn.1001-6325.2022.11.1771

脐带间充质干细胞修复皮肤创伤的研究进展

吴文哲¹, 孙建伟³, 付长秀¹, 黄李晨露¹, 郑永钦², 贺军栋^2*

1.昆明理工大学医学院,云南昆明 650000;
昆明理工大学附属医院云南省第一人民医院 2.内分泌代谢科; 3.乳腺甲状腺外科,云南昆明 650000

收稿日期:2021-06-03 修回日期:2021-11-25 出版日期:2022-11-05 发布日期:2022-11-01
通讯作者: ^* hejd1227@163.com
基金资助:
云南省中青年学术和技术带头人后备人才(2018HB050);云南省“万人计划”青年拔尖人才专项(YNWR-QNBJ-2018-070)

Research progress of umbilical cord mesenchymal stem cells in repairing skin wounds

WU Wen-zhe¹, SUN Jian-wei³, FU Chang-xiu¹, HUANG Li-chen-lu¹, ZHENG Yong-qin², HE Jun-dong^2*

1. Medical Faculty, Kunming University of Science and Technology, Kunming 650000;
2. Department of Endocrinology and Metabolism; 3. Department of Breast and Thyroid Surgery, the First People's Hospital of Yunnan Province,the Affiliated Hospital of Kunming University of Science and Technology, Kunming 650000,China

Received:2021-06-03 Revised:2021-11-25 Online:2022-11-05 Published:2022-11-01
Contact: ^* hejd1227@163.com

摘要/Abstract

摘要： 脐带间充质干细胞(UC-MSCs)是一种免疫原性低、易于获取和扩增的成体干细胞。UC-MSCs可以调节伤口炎性反应水平,促进血管形成、细胞增殖,抑制瘢痕形成,诱导皮肤附件形成。UC-MSCs联合其他药物作用于伤口可以促进UC-MSCs的黏附、存活、迁移和增殖等。

关键词: 脐带间充质干细胞, 炎性反应, 增殖, 黏附, 迁移

Abstract: Umbilical cord mesenchymal stem cells (UC-MSCs) are a kind of adult stem cells with low immunogenicity, which are easy to collect and to expand in vitro. UC-MSCs can regulate wound inflammation, promote angiogenesis and cell proliferation, inhibit scar formation and induce the formation of skin appendages. UC-MSCs combined with other drugs can promote the adhesion, survival, migration and proliferation of UC-MSCs.

Key words: umbilical cord mesenchymal stem cells, inflammation response, proliferation, adhesion, migration

中图分类号:

R392.12

吴文哲, 孙建伟, 付长秀, 黄李晨露, 郑永钦, 贺军栋. 脐带间充质干细胞修复皮肤创伤的研究进展[J]. 基础医学与临床, 2022, 42(11): 1771-1775.

WU Wen-zhe, SUN Jian-wei, FU Chang-xiu, HUANG Li-chen-lu, ZHENG Yong-qin, HE Jun-dong. Research progress of umbilical cord mesenchymal stem cells in repairing skin wounds[J]. Basic & Clinical Medicine, 2022, 42(11): 1771-1775.

参考文献 29

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脐带间充质干细胞修复皮肤创伤的研究进展

Research progress of umbilical cord mesenchymal stem cells in repairing skin wounds

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