胆汁淤积性肝损伤炎性反应机制的研究进展

doi:10.16352/j.issn.1001-6325.2022.05.002

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (5): 809-813.doi: 10.16352/j.issn.1001-6325.2022.05.002

胆汁淤积性肝损伤炎性反应机制的研究进展

康锦钰¹, 罗佳¹, 高泽天¹, 郑文涛¹, 刘爱明¹, 宋毓飞^2*

1.宁波大学医学院, 浙江宁波 315211;
2.宁波大学附属李惠利医院, 浙江宁波 315211

收稿日期:2021-02-09 修回日期:2021-06-08 出版日期:2022-05-05 发布日期:2022-04-28
通讯作者: * songyufei2017@126.com
基金资助:
浙江省基础公益研究计划项目(LGF19H030008,LY20H030001,LGD19H070001);宁波市公益类科技计划项目(202002N3160)

Research progress on the inflammatory mechanisms of cholestatic liver injury

KANG Jin-yu¹, LUO Jia¹, GAO Ze-tian¹, ZHENG Wen-tao¹, LIU Ai-ming¹, SONG Yu-fei^2*

1. School of Medicine, Ningbo University, Ningbo 315211;
2. the Affiliated Lihuili Hospital, Ningbo University, Ningbo 315211, China

Received:2021-02-09 Revised:2021-06-08 Online:2022-05-05 Published:2022-04-28
Contact: * songyufei2017@126.com

摘要/Abstract

摘要： 胆汁淤积性肝损伤(CLI)是临床常见肝脏疾病,其生化本质是各种原因导致胆汁酸异常蓄积,使系统胆汁酸暴露增加,并在肝脏内造成肝细胞损伤。若病情持续进展,可以发展为肝纤维化、肝硬化、肝衰竭和肝癌等疾病。本文聚焦于胆汁淤积引发肝细胞损伤的生物学环节,从炎性反应的角度探讨胆汁淤积导致肝损伤的分子机制,将对中性粒细胞、巨噬细胞(Kupffer细胞)及胆管细胞等在CLI相关炎性反应中作用以及介导CLI相关炎性反应的信号通路进行阐述,为寻找新的治疗靶点和治疗策略提供思路。

关键词: 胆汁淤积, 肝损伤, 炎性反应, 中性粒细胞, c-Jun氨基末端激酶

Abstract: Cholestatic liver injury (CLI) is a liver disease with high mordity. Accumulation of bile acids in the liver is thought to be a major driver of liver injury during cholestasis. The disease can develop into be liver fibrosis, cirrhosis, liver failure and liver cancer. This review focuses on the molecular mechanism of CLI in the perspective of inflammatory response. The roles of neutrophils, Kupffer cells, bile duct cells, and the signaling pathways involved in CLI are reviewed to provide clues for research of new therapeutic targets and treatment strategies.

Key words: cholestatasis, liver injury, inflammation, neutrophils, c-Jun N-terminal kinase

中图分类号:

R575

康锦钰, 罗佳, 高泽天, 郑文涛, 刘爱明, 宋毓飞. 胆汁淤积性肝损伤炎性反应机制的研究进展[J]. 基础医学与临床, 2022, 42(5): 809-813.

KANG Jin-yu, LUO Jia, GAO Ze-tian, ZHENG Wen-tao, LIU Ai-ming, SONG Yu-fei. Research progress on the inflammatory mechanisms of cholestatic liver injury[J]. Basic & Clinical Medicine, 2022, 42(5): 809-813.

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胆汁淤积性肝损伤炎性反应机制的研究进展

Research progress on the inflammatory mechanisms of cholestatic liver injury

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