肠道菌群与衰弱关系的研究进展

基础医学与临床 ›› 2021, Vol. 41 ›› Issue (1): 108-111.

肠道菌群与衰弱关系的研究进展

牛晓丹, 郭静波, 王惠琳, 迟俊婷, 阮海慧, 陶红霞, 王艳红^*

兰州大学护理学院, 甘肃兰州 730000

收稿日期:2020-03-01 修回日期:2020-05-27 出版日期:2021-01-05 发布日期:2020-12-30
通讯作者: ^*yanghongwang@lzu.edu.cn
基金资助:
国家自然科学基金(71804064);中央高校基本科研业务费专项资金(lzujbky-2017-16)

Advances in research on the relationship between intestinal microbiota and frailty

NIU Xiao-dan, GUO Jing-bo, WANG Hui-lin, CHI Jun-ting, RUAN Hai-hui, TAO Hong-xia, WANG Yan-hong^*

School of Nursing, Lanzhou University, Lanzhou 730030, China

Received:2020-03-01 Revised:2020-05-27 Online:2021-01-05 Published:2020-12-30
Contact: ^*yanghongwang@lzu.edu.cn

摘要/Abstract

摘要： 人体肠道菌群数量庞大,种类繁多,且随年龄的增长不断发生着变化。肠道菌群与老年人的衰弱状况密切相关,肠道菌群可通过各种途径参与衰弱的发生发展。因此,研究衰弱老年人肠道菌群特征、衰弱与肠道菌群的关系,对调整衰弱老年人肠道菌群具有重要意义,可使处于衰弱风险的老年人得到及时和必要的干预与帮助。

关键词: 肠道菌群, 衰弱, 衰弱表型, 认知衰弱

Abstract: The quantity of human intestinal microbiota is large and diverse, its changes with age. Intestinal microbiota is closely related to the frailty of the elderly, and can be potential risk factor in the occurrence and development of frailty with different mechanisms. Therefore, the study of the relationship between frailty and intestinal microbiota in elderly patients is of great significance to the regulation of intestinal microbiota in elderly patients with frailty, so that the elderly at risk of frailty can get timely and necessary intervention and help.

Key words: intestinal microbiota, frailty, frailty phenotype, cognitive frailty

中图分类号:

R592

牛晓丹, 郭静波, 王惠琳, 迟俊婷, 阮海慧, 陶红霞, 王艳红. 肠道菌群与衰弱关系的研究进展[J]. 基础医学与临床, 2021, 41(1): 108-111.

NIU Xiao-dan, GUO Jing-bo, WANG Hui-lin, CHI Jun-ting, RUAN Hai-hui, TAO Hong-xia, WANG Yan-hong. Advances in research on the relationship between intestinal microbiota and frailty[J]. Basic & Clinical Medicine, 2021, 41(1): 108-111.

参考文献

[1] 李阳, 张立萍, 罗洋. 哈尔滨市社区老年人衰弱现状及其影响因素调查[J]. 护理研究, 2018, 32: 224-228.
[2] Fried LP, Tangen CM. Frailty in older adults: evidence for a phenotype[J]. J Gerontol A Biol Sci Med Sci, 2001, 56: 146-156.
[3] Biagi E, Rampelli S, Turroni S, et al. The gut microbiota of centenarians: signatures of longevity in the gut microbiota profile[J]. Mech Ageing Dev, 2017, 165: 180-184.
[4] Van Tongeren SP, Slaets JP, Harmsen HJ, et al. Fecal microbiota composition and frailty[J]. Appl Environ Microbiol, 2005, 71: 6438-6442.
[5] Zhang L, Liao J, Chen Q, et al. Characterization of the gut microbiota in frail elderly patients[J]. Aging Clin Exp Res, 2019, 26: 1-11.
[6] Jackson MA, Jeffery IB, Beaumont M, et al. Signatures of early frailty in the gut microbiota[J]. Genome Med, 2016, 8: 8-18.
[7] Theou O, Jayanama K, Fernández-Garrido J, et al. Can a prebiotic formulation reduce frailty levels in older people?[J]. J Frailty Aging, 2019, 8: 48-52.
[8] Buigues C, Fernández-Garrido J, Pruimboom L, et al. Effect of a prebiotic formulation on frailty syndrome:a randomized, double-blind clinical trial[J]. Int J Mol Sci, 2016, 17: 932-943.
[9] Leng S, Chaves P, Koenig K, et al. Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty:a pilot study[J]. J Am Geriatr Soc, 2002, 50: 1268-1271.
[10] Thevaranjan N, Puchta A, Schulz C, et al. Age-asso-ciated microbial dysbiosis promotes intestinal permeabi-lity, systemic inflammation, and macrophage dysfunction[J]. Cell Host Microbe, 2017, 21: 455-466.
[11] 刘晓蕾, 岳冀蓉, 乔闰娟, 等. 肠道菌群在肌少症发病机制中的作用[J]. 实用老年医学, 2019, 33: 840-843.
[12] 李姝敏, 汪晶美, 李晗宇, 等. 老年肌少症患者骨骼肌质量指数与肥胖、骨质疏松及肠道菌群的相关性研究[J]. 中华危重症医学杂志(电子版), 2018, 11: 7-11.
[13] Andrea T, Fulvio L, Christian M, et al. Aging gut microbiota at the cross-road between nutrition, physical frailty, and sarcopenia:is there a gut-muscle axis?[J]. Nutrients, 2017, 9: 1303-1322.
[14] Virtuoso Júnior JS, Roza LB, Tribess S, et al. Time spent sitting is associated with changes in biomarkers of frailty in hospitalized older adults:a cross sectional study[J]. Front Physiol, 2017, 8: 505-510.
[15] 贺莹莹, 王艺蕊, 何辉, 等. 不同体力活动水平对女性肠道菌群的影响[J]. 航天医学与医学工程, 2019, 32: 420-425.
[16] 于春霞, 傅力. 肠道菌群-运动干预防治代谢性疾病的新靶点[J]. 中国运动医学杂志, 2017, 36: 443-447.
[17] Schretter CE, Vielmetter J, Bartos I, et al. A gut micro-bial factor modulates locomotor behaviour in Drosophil[J]. Nature, 2018, 563: 402-406.
[18] Scheperjans F, Aho V, Pereira PAB, et al. Gut microbiota are related to Parkinson's disease and clinical phenotype[J]. Mov Disord, 2015, 30: 350-358.
[19] Morita E, Yokohama H, Imai D, et al. Aerobic exercise training with brisk walking increases intestinal Bacteroides in elderly women[J]. Nutrients, 2019, 11: 868-884.
[20] Frémont M, Coomans D, Massart S, et al. High-through-put 16S rRNA gene sequencing reveals alterations of intestinal microbiota in myalgic encephalomyelitis/chronic fatigue syndrome patients[J]. Anaerobe, 2013, 22: 50-56.
[21] Logan AC, Venket Rao A, Irani D. Chronic fatigue syndrome:lactic acid bacteria may be of therapeutic value[J]. Med Hypothesis, 2003, 60: 915-923.
[22] Sheedy JR, Wettenhall RE, Scanlon D, et al. Increased D-lactic acid intestinal bacteria in patients with chronic fatigue syndrome[J]. In Vivo, 2009, 23: 621-628.
[23] Bajaj JS, Ridlon JM, Hylemon PB, et al. Linkage of gut microbiome with cognition in hepatic encephalopathy[J]. Am J Physiol Gastrointest Liver Physiol, 2012, 302: 168-175.
[24] Vogt NM, Kerby RL, Dill-Mcfarland KA, et al. Gut microbiome alterations in Alzheimer's disease[J]. Sci Rep, 2017, 7: 13537.doi:10.1038/s41598-017-13601-Y.
[25] Cattaneo A, Cattane N, Galluzzi S, et al. Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly[J]. Neurobiol Aging, 2017, 49: 60-68.