›› 2019, Vol. 39 ›› Issue (11): 1639-1643.

• 短篇综述 • 上一篇    下一篇

VCAM-1与VLA-4相互作用与肿瘤关系的研究进展

李生军1,李向茸2,冯若飞2   

  1. 1. 西北民族大学 生物医学研究中心
    2. 西北民族大学
  • 收稿日期:2019-03-04 修回日期:2019-07-09 出版日期:2019-11-05 发布日期:2019-11-05
  • 通讯作者: 李生军 E-mail:1778435738@qq.com
  • 基金资助:
    国家自然科学基金项目;教育部“创新团队发展计划”项目;西北民族大学“双一流”引导专项生物工程特色学科

Advances in research on the relationship between VCAM-1 and VLA-4 interactions and tumors

1, 1,ruofei ruofeiFeng   

  • Received:2019-03-04 Revised:2019-07-09 Online:2019-11-05 Published:2019-11-05

摘要: 晚期抗原4(VLA-4)与血管细胞黏附分子1(VCAM-1)互为配体,VLA-4能与VCAM-1的第1结构域或第4结构域的特异性结合。并在VCAM-1的结构域1和结构域4中发现的6个线性氨基酸序列对两者的特异性结合起着至关重要的作用。VLA-4和VCAM-1在多种疾病中都高表达并与许多疾病的发病机制有着密不可分的联系。

关键词: VCAM-1, VLA-4, NF-κB, 肿瘤

Abstract: The late antigen 4(VLA-4) and the vascular cell adhesion molecule 1(VCAM-1) are ligands to each other, and the late antigen 4 can specifically bind to the first domain or the fourth domain of the vascular cell adhesion molecule1,and six linear amino acid sequences found in domain 1 and domain 4 of vascular cell adhesion molecules, and this sequence plays a crucial role in the specific binding of the two.Advanced antigen-4 and vascular cell adhesion molecule-1 are highly expressed in many diseases and are inextricably linked to the pathogenesis of many diseases.

Key words: VCAM-1, VLA-4, NF-κB, tumour