巨噬细胞胞外诱捕网在炎性疾病中的作用

doi:10.16352/j.issn.1001-6325.2025.10.1368

基础医学与临床 ›› 2025, Vol. 45 ›› Issue (10): 1368-1371.doi: 10.16352/j.issn.1001-6325.2025.10.1368

巨噬细胞胞外诱捕网在炎性疾病中的作用

吴倩倩, 马楷婷, 曹凌飞, 王晓萍^*

新乡医学院基础医学院,河南新乡 453000

收稿日期:2024-11-12 修回日期:2025-02-26 出版日期:2025-10-05 发布日期:2025-09-22
通讯作者: ^*221026@xxmu.edu.cn
基金资助:
河南省科技攻关项目(252102311133);河南省大学生创新训练计划(202410472017)

Role of macrophage extracellular traps in inflammatory diseases

WU Qianqian, MA Kaiting, CAO Lingfei, WANG Xiaoping^*

School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453000, China

Received:2024-11-12 Revised:2025-02-26 Online:2025-10-05 Published:2025-09-22
Contact: ^*221026@xxmu.edu.cn

摘要/Abstract

摘要： 巨噬细胞胞外诱捕网(METs) 是由巨噬细胞产生的细胞外纤维网状结构。在生理情况下,METs通过释放高浓度的颗粒蛋白捕获并杀死病原微生物,是机体的一种先天性免疫防御机制,对抵抗炎性反应进展起到重要的保护作用。METs过度释放同样能导致机体炎性反应加剧,造成组织进一步损伤。

关键词: 巨噬细胞, 巨噬细胞胞外诱捕网, 炎性疾病

Abstract: Macrophage extracellular traps (METs) are extracellular fibrous web-like structures produced by macrophages. Under physiological conditions, METs capture and kill microorganisms by releasing high concentrations of granular proteins, serving as an innate immune defense mechanism and playing a vital protective role in resisting the progression of inflammatory diseases. Excessive release of METs can also exacerbate the inflammatory response and cause further tissue damage.

Key words: macrophage, macrophage extracellular traps, inflammatory disease

中图分类号:

R364.7

吴倩倩, 马楷婷, 曹凌飞, 王晓萍. 巨噬细胞胞外诱捕网在炎性疾病中的作用[J]. 基础医学与临床, 2025, 45(10): 1368-1371.

WU Qianqian, MA Kaiting, CAO Lingfei, WANG Xiaoping. Role of macrophage extracellular traps in inflammatory diseases[J]. Basic & Clinical Medicine, 2025, 45(10): 1368-1371.

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巨噬细胞胞外诱捕网在炎性疾病中的作用

Role of macrophage extracellular traps in inflammatory diseases

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