幽门螺杆菌感染引起胃黏膜解痉多肽表达化生机制

doi:10.16352/j.issn.1001-6325.2025.01.0130

基础医学与临床 ›› 2025, Vol. 45 ›› Issue (1): 130-134.doi: 10.16352/j.issn.1001-6325.2025.01.0130

幽门螺杆菌感染引起胃黏膜解痉多肽表达化生机制

王海诺¹, 李玙璠¹, 王雨莹², 沈倩影³, 朱进霞³, 郑丽飞^3*

首都医科大学基础医学院 1.2020级五年制临床医学专业; 2.2020级五年制基础医学专业; 3.生理学与病理生理学系,北京 100069

收稿日期:2024-05-21 修回日期:2024-07-08 出版日期:2025-01-05 发布日期:2024-12-25
通讯作者: ^*13581582937@163.com
基金资助:
首都医科大学2021年度第二课堂项目(D2KT2021037);科技部重点专项(2016YFC1302203)

Mechanism of spasmolytic polypeptide-expressing metaplasia in gastric mucosa induced by Helicobacter pylori infection

WANG Hainuo¹, LI Yufan¹, WANG Yuying², SHEN Qianying³, ZHU Jinxia³, ZHENG Lifei^3*

1. Department of Grade 2020 Five-year Clinical Medicine; 2. Department of Grade 2020 Five-year Basic Medicine; 3. Department of Physiology and Pathophysiology, Basic Medical College, Capital Medical University, Beijing 100069, China

Received:2024-05-21 Revised:2024-07-08 Online:2025-01-05 Published:2024-12-25
Contact: ^*13581582937@163.com

摘要/Abstract

摘要： 幽门螺杆菌(H.pylori)感染后胃黏膜会发生炎性反应和解痉多肽表达化生(SPEM)。这些病症会进一步诱导慢性胃炎、胃溃疡,甚至胃癌。因此,SPEM通常被认为是胃黏膜损伤和癌变的早期指标之一。阐明H.pylori诱导的SPEM细胞来源和分子调控可以更深入地了解相关胃黏膜疾病的发病机制,并为其疾病的诊断和治疗提供新的思路和靶点。本文对SPEM相关的分子标志物进行了总结,阐述了TFF2、CD44v9和AQP5在H.pylori感染和SPEM中的调控作用。对SPEM细胞的起源以及相关分子调控机制进行了综述。

关键词: 幽门螺杆菌, 胃黏膜解痉多肽表达化生

Abstract: Helicobacter pylori(H. pylori) infection triggers gastric mucosal inflammatory responses and spasmolytic polypeptide-expressing metaplasia (SPEM). These pathological conditions can escalate the severity of chronic gastritis, gastric ulcers and even cause gastric cancer. SPEM is frequently viewed as an early sign of gastric mucosal injury and the onset of carcinogenesis. A comprehensive analysis of the genesis and molecular regulation of SPEM cells in the context of H. pylori infection further has enlightened the pathogenesis of gastric mucosal diseases and provide new ideas and targets for diagnosing and treatment of H. pylori-related gastric mucosal diseases. This paper reviews a variety of molecular biomarkers associated with SPEM, encompassing TFF2, CD44v9, and AQP5, and delineates their pivotal regulatory functions in H.pylori infection and SPEM. This paper also reviews the origination of SPEM cells and pertinent molecular regulatory mechanisms.

Key words: Helicobacter pylori, spasmolytic polypeptide-expressing metaplasia

中图分类号:

R378.2

王海诺, 李玙璠, 王雨莹, 沈倩影, 朱进霞, 郑丽飞. 幽门螺杆菌感染引起胃黏膜解痉多肽表达化生机制[J]. 基础医学与临床, 2025, 45(1): 130-134.

WANG Hainuo, LI Yufan, WANG Yuying, SHEN Qianying, ZHU Jinxia, ZHENG Lifei. Mechanism of spasmolytic polypeptide-expressing metaplasia in gastric mucosa induced by Helicobacter pylori infection[J]. Basic & Clinical Medicine, 2025, 45(1): 130-134.

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幽门螺杆菌感染引起胃黏膜解痉多肽表达化生机制

Mechanism of spasmolytic polypeptide-expressing metaplasia in gastric mucosa induced by Helicobacter pylori infection

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