基础医学与临床 ›› 2024, Vol. 44 ›› Issue (10): 1451-1454.doi: 10.16352/j.issn.1001-6325.2024.10.1451

• 短篇综述 • 上一篇    下一篇

Apelin在女性生殖健康中的研究进展

陈琳1, 李瑞雪1, 王宏羽1, 尹海燕2, 郭岩2*   

  1. 济宁医学院1.临床医学院; 2.基础医学院,山东 济宁 272067
  • 收稿日期:2023-11-30 修回日期:2024-04-02 出版日期:2024-10-05 发布日期:2024-09-27
  • 通讯作者: * 15166798126@163.com
  • 基金资助:
    国家自然科学基金(82000979);济宁医学院2022年大学生创新训练计划项目(cx2022070z)

Research progress of Apelin in female reproductive health

CHEN Lin1, LI Ruixue1, WANG Hongyu1, YIN Haiyan2, GUO Yan2*   

  1. 1. Clinical Medical College; 2. Basic Medical College,Jining Medical University,Jining 272067,China
  • Received:2023-11-30 Revised:2024-04-02 Online:2024-10-05 Published:2024-09-27
  • Contact: * 15166798126@163.com

摘要: Apelin是一种脂肪因子,包括Apelin-13、Apelin-36等多种亚型,通过参与免疫调节、氧化应激、糖脂代谢、细胞凋亡等调节生理功能。Apelin与多囊卵巢综合征、卵巢癌等女性生殖系统疾病密切相关,有望为此类疾病的进一步研究及治疗提供靶点与方向。

关键词: Apelin, 卵巢, 颗粒细胞, 脂肪因子, 子宫内膜

Abstract: Apelin is an adipokine family which includes Apelin-13, Apelin-36 and other isoforms and regulates physiological functions by immunomodulation, oxidative stress, glycolipid metabolism, and apoptosis and so on. Apelin is closely related to polycystic ovary syndrome, ovarian cancer and other diseases of the female reproductive system so it is expected to be new target molecules and may orient the development of research and clinical treatment.

Key words: Apelin, ovary, granulosa cells, adipokine, endometrium

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