HMGB1信号通路在支气管哮喘中作用的研究进展

doi:10.16352/j.issn.1001-6325.2023.04.0690

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (4): 690-694.doi: 10.16352/j.issn.1001-6325.2023.04.0690

HMGB1信号通路在支气管哮喘中作用的研究进展

孙莹¹, 杨治安¹, 何瑶¹, 余勤^2*

1.兰州大学第一临床医学院,甘肃兰州 730000;
2.兰州大学第一医院呼吸科,甘肃兰州 730000

收稿日期:2021-12-31 修回日期:2022-05-31 出版日期:2023-04-05 发布日期:2023-04-03
通讯作者: ^*yuq701@163.com
基金资助:
甘肃省科技计划(18YF1FA106)

Research progress on the role of HMGB1 signal pathway in bronchial asthma

SUN Ying¹, YANG Zhian¹, HE Yao¹, YU Qin^2*

1. the First School of Clinical Medcine, Lanzhou University, Lanzhou 730000;
2. Department of Respiratory, the First Hospital of Lanzhou University,Lanzhou 730000,China

Received:2021-12-31 Revised:2022-05-31 Online:2023-04-05 Published:2023-04-03
Contact: ^*yuq701@163.com

摘要/Abstract

摘要： 高迁移率族蛋白B1(HMGB1) 作为一种普遍存在的核蛋白,几乎在所有细胞中都有表达,激活释放后与其受体结合介导肺部炎性反应。HMGB1信号通路与支气管哮喘疾病的发生发展息息相关,相关的靶向药物治疗相继在动物实验以及临床试验中开展。

关键词: 高迁移率族蛋白B1 , 支气管哮喘, 气道炎性反应, 气道重塑

Abstract: High mobility group box 1 protein (HMGB1), as a ubiquitous nuclear protein, expresses in almost all cells. After activation and release, HMGB1 binds to its receptor and mediates pulmonary inflammatory response. HMGB1 signaling pathway is closely related to the occurrence and development of bronchial asthma. Related targeted drug therapy has been carried out in animal test and in clinical trials.

Key words: HMGB1, bronchial asthma, airway inflammation, airway remodeling

中图分类号:

R563.9

孙莹, 杨治安, 何瑶, 余勤. HMGB1信号通路在支气管哮喘中作用的研究进展[J]. 基础医学与临床, 2023, 43(4): 690-694.

SUN Ying, YANG Zhian, HE Yao, YU Qin. Research progress on the role of HMGB1 signal pathway in bronchial asthma[J]. Basic & Clinical Medicine, 2023, 43(4): 690-694.

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HMGB1信号通路在支气管哮喘中作用的研究进展

Research progress on the role of HMGB1 signal pathway in bronchial asthma

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