脂肪因子在老年人肌少症发病中作用的研究进展

doi:10.16352/j.issn.1001-6325.2023.04.0695

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (4): 695-699.doi: 10.16352/j.issn.1001-6325.2023.04.0695

脂肪因子在老年人肌少症发病中作用的研究进展

党彩虹¹, 李维辛^2*

1.兰州大学第一临床医学院,甘肃兰州 730000;
2.兰州大学第一医院老年病科二病区,甘肃兰州 730000

收稿日期:2022-11-18 修回日期:2023-02-15 出版日期:2023-04-05 发布日期:2023-04-03
通讯作者: ^*1051742798@qq.com
基金资助:
甘肃省自然科学基金(22JR5RA925)

Research progress on the role of adipokines in the pathogenesis of sarcopenia in the elderly

DANG Caihong¹, LI Weixin^2*

1. the First School of Clinical Medicine, Lanzhou University, Lanzhou 730000;
2. the Second Ward, Department of Geriatrics, the First Hospital of Lanzhou University, Lanzhou 730000, China

Received:2022-11-18 Revised:2023-02-15 Online:2023-04-05 Published:2023-04-03
Contact: ^*1051742798@qq.com

摘要/Abstract

摘要： 衰老进程中脂肪分布的变化、身体活动的减少以及疾病的影响会使机体脂肪因子的循环水平发生改变。脂肪因子可通过调节炎性反应过程、激活/抑制物质代谢信号传导途径发挥促炎/抗炎、调节葡萄糖稳态及能量代谢作用,参与衰老机体肌肉衰减的发生与发展。关注脂肪因子在老年人肌少症中的作用,有助于肌肉衰减的防治。

关键词: 脂肪因子, 老年人, 肌少症

Abstract: The change of fat distribution, the decrease of physical activity and the influence of diseases during aging will change the circulating level of adipokines. Adipokines may promote inflammation or anti-inflammation response, and keep glucose homeostasis and energy metabolism by regulating inflammatory reaction. Adipokines activate or inhibit the signal transduction pathway of substance metabolism, and play a role in the occurrence and development of muscle attenuation of aging organs. Paying attention to the role of adipokines in muscle attenuation will support the prevention and treatment of sarcopenia in the elderly.

Key words: adipokines, the elderly, sarcopenia

中图分类号:

R592

党彩虹, 李维辛. 脂肪因子在老年人肌少症发病中作用的研究进展[J]. 基础医学与临床, 2023, 43(4): 695-699.

DANG Caihong, LI Weixin. Research progress on the role of adipokines in the pathogenesis of sarcopenia in the elderly[J]. Basic & Clinical Medicine, 2023, 43(4): 695-699.

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脂肪因子在老年人肌少症发病中作用的研究进展

Research progress on the role of adipokines in the pathogenesis of sarcopenia in the elderly

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