人体铁代谢及其调控因素

doi:10.16352/j.issn.1001-6325.2022.05.017

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (5): 818-823.doi: 10.16352/j.issn.1001-6325.2022.05.017

人体铁代谢及其调控因素

陈春梅, 葛品, 郭翀^*

福建省妇幼保健院福建医科大学附属医院儿童保健科, 福建福州 350005

收稿日期:2020-12-31 修回日期:2021-06-15 出版日期:2022-05-05 发布日期:2022-04-28
通讯作者: * guochong_joy@163.com
基金资助:
福建医科大学启航基金(2018QH1189); 福建省卫生健康青年科研课题(2019-2-13)

Iron metabolism in human body and its regulatory factors

CHEN Chun-mei, GE Pin, GUO Chong^*

Department of Child Healthcare, the Affiliated Hospital of Fujian Medical University, Fujian Maternity and Child Health Hospital, Fuzhou 350005,China

Received:2020-12-31 Revised:2021-06-15 Online:2022-05-05 Published:2022-04-28
Contact: * guochong_joy@163.com

摘要/Abstract

摘要： 本文从铁的吸收、转运、利用、储存过程阐述人体铁代谢的分子学机制,着重讨论铁代谢过程中的关键蛋白及其相关的调控因素,明确该机制能期望为更早期、更精准的铁稳态失衡标志物的发现提供新思路,并为未来的靶向治疗提供切入点。

关键词: 铁代谢, 二价金属转运蛋白1(DMT1), 铁转运蛋白1(FPN1), 铁调素

Abstract: This article reviews the molecular mechanism of iron metabolism covering iron absorption,transportation,utilization and storage with focus on the key proteins involved in iron metabolism and elaborate regulation factors. Based on these results of research it might be able to provide some new strategies to find potential biomarkers of iron metabolism to support early and correct diagnosis. What's more, a clear mechanism may also provide a breakthrough point for the targeted treatment of iron metabolism disorders in future.

Key words: iron metabolism, divalent metal transporter (DMT1), ferroportin 1(FPN1), hepcidin

中图分类号:

R153.2

陈春梅, 葛品, 郭翀. 人体铁代谢及其调控因素[J]. 基础医学与临床, 2022, 42(5): 818-823.

CHEN Chun-mei, GE Pin, GUO Chong. Iron metabolism in human body and its regulatory factors[J]. Basic & Clinical Medicine, 2022, 42(5): 818-823.

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人体铁代谢及其调控因素

Iron metabolism in human body and its regulatory factors

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