NAD+代谢在细胞功能及相关疾病中作用的研究进展

doi:10.16352/j.issn.1001-6325.2022.02.014

基础医学与临床 ›› 2022, Vol. 42 ›› Issue (2): 306-310.doi: 10.16352/j.issn.1001-6325.2022.02.014

NAD⁺代谢在细胞功能及相关疾病中作用的研究进展

何盛梅^1,2, 赵厚育^1,2*

1.贵州医科大学,贵州贵阳 550004;
2.贵州医科大学附属医院耳鼻咽喉头颈外科,贵州贵阳 550004

收稿日期:2020-10-16 修回日期:2020-12-31 发布日期:2022-01-24
通讯作者: ^* 1911095370@qq.com
基金资助:
国家自然科学基金(81860387);贵州省科技计划项目(黔科合基础[2020]1Y311);贵州医科大学附属医院2020年国家自然科学基金培育项目(I-2020-10)

Research progress on the role of NAD⁺ metabolism in cell function and related-diseases

HE Sheng-mei^1,2, ZHAO Hou-yu^1,2*

1. Guizhou Medical University, Guiyang 550004;
2. Department of Otorhinolaryngology Head and Neck Surgery, the Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China

Received:2020-10-16 Revised:2020-12-31 Published:2022-01-24
Contact: ^* 1911095370@qq.com

摘要/Abstract

摘要： 烟酰胺腺嘌呤二核苷酸(NAD⁺)是细胞内一种重要的辅助调节因子,NAD⁺代谢紊乱与细胞功能损伤、生理改变及疾病的发生发展密切相关。在衰老、听力障碍、心脏损伤等代谢性和年龄相关性疾病的发生过程中都伴随着NAD⁺水平下降,因此,通过补充恢复NAD⁺水平可为这些疾病的治疗提供了一种新思路。

关键词: 烟酰胺腺嘌呤二核苷酸, 代谢, 衰老, 听力障碍, 心脏损伤

Abstract: Nicotinamide adenine dinucleotide (NAD⁺) is an important coregulatory factor in cells. The metabolic disorder of NAD⁺ is closely related to the damage of cell function, physiological changes and the occurrence and development of diseases. The decrease of NAD⁺ level is accompanied by the occurrence of metabolic and age-related diseases such as aging, hearing impairment and cardiac damage.Therefore, it provides a new idea for the treatment of these diseases by supplementing and restoring the level of NAD⁺.

Key words: nicotinamide adenine dinucleotide, metabolism, aging, hearing impairment, cardiac damage

中图分类号:

何盛梅, 赵厚育. NAD⁺代谢在细胞功能及相关疾病中作用的研究进展[J]. 基础医学与临床, 2022, 42(2): 306-310.

HE Sheng-mei, ZHAO Hou-yu. Research progress on the role of NAD⁺ metabolism in cell function and related-diseases[J]. Basic & Clinical Medicine, 2022, 42(2): 306-310.

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NAD⁺代谢在细胞功能及相关疾病中作用的研究进展

Research progress on the role of NAD⁺ metabolism in cell function and related-diseases

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NAD+代谢在细胞功能及相关疾病中作用的研究进展

Research progress on the role of NAD+ metabolism in cell function and related-diseases

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NAD⁺代谢在细胞功能及相关疾病中作用的研究进展

Research progress on the role of NAD⁺ metabolism in cell function and related-diseases