关键词: miRNA, 心脏重塑, 纤维化, 肥大

Abstract: microRNAs (miRNAs) are involved in embryonic development, cell proliferation, differentiation and apoptosis through post-transcriptional regulation of their target genes, and are closely related to the occurrence and development of cardiovascular diseases. Cardiac remodeling currently lacks effective therapeutic targets and effective diagnostic markers, and the mechanism of cardiac remodeling is not deep enough. It has been found that miRNAs can regulate myocardial fibrosis, cardiac hypertrophy, and energy metabolism regulation and remodeling through different molecular mechanisms.

Key words: miRNAs, cardiac remodeling, fibrosis, hypertrophy