基础医学与临床 ›› 2018, Vol. 38 ›› Issue (11): 1615-1619.

• 短篇综述 • 上一篇    下一篇

外泌体在肝癌中的研究进展及应用前景

徐先云1,严俊2,李汛2   

  1. 1. 兰州大学
    2. 兰州大学第一医院
  • 收稿日期:2017-07-31 修回日期:2017-11-06 出版日期:2018-11-05 发布日期:2018-11-22
  • 通讯作者: 李汛 E-mail:lxdr21@126.com
  • 基金资助:
    慢性镉胁迫诱导机体肝癌发生的DNA甲基化修饰效应;甘肃省科技重大专项(1602FKDA001)-细胞精准治疗甘肃重大及高发慢病的医学转化体系建立

Research progress and application prospect of exosomes in hepatocellular carcinoma

1, Xun LI   

  • Received:2017-07-31 Revised:2017-11-06 Online:2018-11-05 Published:2018-11-22
  • Contact: Xun LI E-mail:lxdr21@126.com

摘要: 外泌体是一种重要的细胞间物质和信息交流的工具,它通过细胞间传递基因和蛋白信号,调节肿瘤微环境,进而介导肿瘤细胞的凋亡、分化、血管生成和转移。外泌体通过多种机制促进肝癌的发生发展,其在肝癌的早期诊断、耐药性检测、预后评估及治疗均密切相关。因此,对于外泌体的研究,可为肝癌的治疗提供新的方向和机遇。

关键词: 关键词:肝癌, 外泌体, 诊断, 治疗

Abstract: Exosome is an important intercellular material and information exchange tool. It regulates the tumor microenvironment through the gene and protein signaling, which in turn mediates tumor cell apoptosis, differentiation, angiogenesis and metastasis. The exosome contribute to the development and progression of HCC by a variety of mechanisms. They are closely related to the early diagnosis, drug resistance detection, prognosis evaluation and treatment of HCC. Therefore, the study of the exosome can provide new directions and opportunities for the treatment of HCC.

Key words: Key words:hepatocellular carcinoma, exosomes, Diagnosis, Treatment

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