关键词: 肾脏, 内分泌, FSHR, LHR

Abstract: Objective By studying the characteristics of FSH receptor (FSHR), LH receptor (LHR) in rat renal tissue, further to prove the similar features and changes in renal and ovary, then to reveal the substantial of " The renal governs reproducion " ,to provide the experimental basis for the theory of traditional Chinese medicine, and to add new contents for the physiological functions of the renal. Methods To prepare the model of ovariectomized rats, then to study the characteristics of FSHR, LHR in normal and ovariectomized rat kidney tissue by radioimmunoassay, RT-PCR semi-quantitative methods. Results The two-phase adjustments of FSH, LH receptor in kidney and ovary is same: low doses of FSH, LH increased the level of the FSHRmRNA, LHRmRNA, while high doses of FSH, LH down the level of the FSHRmRNA, LHRmRNA; the treatment of high-dose estrogen significantly decreased the level of the FSHRmRNA, while the death of the fetal kidney cell suspension effectively increased the level of the E2 in ovariectomized rats, reduced the expression of FSHR mRNA. Conclusion The regulation characteristics of the FSHR,LHR was same in rat kidney and ovarian tissues, kidney and ovarian tissues may have similar functions, to participate in the process of the synthesis and regulation of hormone.

Key words: Renal, endocrine, FSHR, LHR