基础医学与临床 ›› 2025, Vol. 45 ›› Issue (7): 958-962.doi: 10.16352/j.issn.1001-6325.2025.07.0958

• 短篇综述 • 上一篇    下一篇

乳酸脱氢酶 A在恶性血液病中的作用

莫玉珍, 陈婷婷, 周合冰*   

  1. 首都医科大学附属北京潞河医院 血液科,北京 101199
  • 收稿日期:2024-11-13 修回日期:2025-02-26 出版日期:2025-07-05 发布日期:2025-06-24
  • 通讯作者: *bjlhyyxyk@ccmu.edu.cn
  • 基金资助:
    通州区高水平双师科技创新培育专项(KJ2023SS007)

Role of lactate dehydrogenase A in malignant hematological diseases

MO Yuzhen, CHEN Tingting, ZHOU Hebing*   

  1. Department of Hematology, Luhe Hospital, Capital Medical University, Beijing 101199, China
  • Received:2024-11-13 Revised:2025-02-26 Online:2025-07-05 Published:2025-06-24
  • Contact: *bjlhyyxyk@ccmu.edu.cn

摘要: 乳酸脱氢酶 A(LDHA)是细胞无氧糖酵解过程中的一种重要的酶,能够催化丙酮酸转化为乳酸,参与肿瘤的增殖、迁移、侵袭和肿瘤微环境的调节等过程。LDHA的高表达常提示恶性血液病的病情发展以及不良预后。LDHA在恶性血液病中的表达与低氧诱导因子1(HIF1)、微小RNA(miRNA)、髓细胞增生原癌基因(c-Myc)等分子以及PI3K/AKT/GSK3、USP1/PLK1/LDHA、Fbw7/LDHA/乳酸/miR-223等信号通路密切相关,而LDHA促进恶性血液病病程进展主要是通过糖酵解调节能量代谢的途径。

关键词: 乳酸脱氢酶 A, 恶性血液病, 糖酵解

Abstract: Lactate dehydrogenase A (LDHA) is an important enzyme involved in the anaerobic glycolysis of cells, catalyzing the conversion of pyruvate to lactate and participating in processes such as tumor proliferation, migration, invasion, and the regulation of the tumor microenvironment. High expression levels of LDHA are often indicative of disease progression and poor prognosis in malignant hematological diseases. The expression of LDHA in malignant hematological diseases is closely associated with various molecules, including HIF-1, microRNAs and c-Myc, as well as signaling pathways like PI3K/AKT/GSK3, USP1/PLK1/LDHA and Fbw7/LDHA/lactate/miR-223. Meanwhile,the progression of malignant hematological conditions facilitated by LDHA primarily occurs through the regulation of energy metabolism via glycolytic pathways.

Key words: lactate dehydrogenase A, malignant hematological disease, glycolysis

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