基础医学与临床 ›› 2025, Vol. 45 ›› Issue (7): 963-968.doi: 10.16352/j.issn.1001-6325.2025.07.0963

• 短篇综述 • 上一篇    下一篇

慢性血栓栓塞性肺动脉高压组学研究进展

段文鑫1, 宋婉璐2, 杨沛然2*, 王婧3   

  1. 1.中国医学科学院 北京协和医学院,北京 100730;
    中国医学科学院基础医学研究所 北京协和医学院基础学院 2.生理学系;3.病理生理学系, 北京 100005
  • 收稿日期:2025-04-22 修回日期:2025-05-20 出版日期:2025-07-05 发布日期:2025-06-24
  • 通讯作者: *peiran.yang@foxmail.com

Progress on omics studies of chronic thromboembolic pulmonary hypertension

DUAN Wenxin1, SONG Wanlu2, YANG Peiran2*, WANG Jing3   

  1. 1. Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730;
    2. Department of Physiology;3. Department of Pathophysiology, Institute of Basic Medical Sciences CAMS, School of Basic Medicine PUMC, Beijing 100005, China
  • Received:2025-04-22 Revised:2025-05-20 Online:2025-07-05 Published:2025-06-24
  • Contact: *peiran.yang@foxmail.com

摘要: 慢性血栓栓塞性肺动脉高压(CTEPH)是一种由肺动脉血栓不溶和慢性栓塞所致的肺动脉高压。近年来,组学技术为CTEPH研究提供了多维视角:单细胞转录组揭示了关键致病细胞亚群及相关机制;基因组发现了与凝血等相关的易感基因;蛋白组识别出与血管重塑密切相关的差异蛋白;代谢组则描绘了代谢重编程特征并发现潜在分型标志物。本文综述了上述组学领域的研究进展,探讨其在机制解析、标志物探索及个体化治疗方面的价值与前景。

关键词: 慢性血栓栓塞性肺动脉高压(CTEPH), 单细胞转录组学, 基因组学, 蛋白组学, 代谢组学

Abstract: Chronic thromboembolic pulmonary hypertension (CTEPH) is a form of pulmonary hypertension caused by unresolved thrombi and chronic embolization in the pulmonary arteries. In recent years, multi-omics technologies have provided multidimensional insights into CTEPH. Single-cell transcriptomics has identified key pathogenic cell subsets and related mechanisms; Genomics has revealed susceptibility genes associated with coagulation; Proteomics has uncovered differentially expressed proteins closely linked to vascular remodeling; And metabolomics has characterized metabolic reprogramming features and potential sub-typing biomarkers. This review summarizes recent advances in these omics fields and discusses their value and prospects in mechanistic exploration, biomarker discovery, and personalized therapeutic strategies.

Key words: chronic thromboembolic pulmonary hypertension(CTEPH), single-cell transcriptomics, genomics, proteomics, metabolomics

中图分类号: